Study of the etiology of spinal and hip fractures due to osteoporesis

用骨质疏松症、骨骼矿物密度（BMD）和骨骼几何学或骨骼代谢状态复杂化的脊柱和髋部断裂的拓扑学被研究了。用双能量X射线吸收率（DXA）设备测量了BMD-600，用中等半径测量了QDR-2000，用第四个荧光垂直和准女性测量了BBMD。作为骨骼标记，吡啶醇（Pyr）、脱氧吡啶醇（D-Pyr）和NTx是可测量的。这本书是为妇女做的。脊柱断裂是根据对初级骨质疏松症的诊断标准进行评判的，然后在脊柱和脊柱上的晚期X射线薄膜的解剖学、中央和后垂直高度的形态测量。由于正向女性、女性轴长度（FAL）和颈部宽度的几何测量，对脊柱断裂的尊重; （1）破碎案例中的放射性、放射性和女性BMDs（N=41）明显较低（p<0.0001-0.0062）比非破碎案例中的那些（N=118-125） ... More .（2）在破碎的情况下，Pyr水平倾向于较高。（3）破碎的案件展示了一个重要的意义（p=0.0092-0.0188）不只是Pyrr和D-Pyrr两个级别增加的情况更高（高于33.2 pmol/mmol/Cr和6.4 pmol/mmol/Cr，相应地），但也降低了BMD水平，低于年轻成年人平均值的70%，在辐射和伦巴尔韦特布雷，与non-fractured cases.With respect to hip fracture ; （1） Femoral neck BMDs were significantly lower（p<0.0001） in the fractured cases （N=76）。（2）臀部断裂的增加奇数比，从逻辑回归分析计算，年龄调整， was 3.40 （p<0.0001）在女性颈部BMD的ISD中降解，1.48 （p=0.0320）在10公斤体重的降解。（3）臀部裂纹的女性颈部BMD的阈值值为0.516克/厘米D12-D1，（4）来自破碎案例（N37）和非破碎案例（N=161）超过70年的时间，一个明显更长的颈部宽度被注意到在破碎案例中比在非破碎案例中，而在两个群体之间没有差异。它被怀疑是因为脊柱断裂与低BMD和增加的骨骼弯曲有关，但臀部断裂与几何学有关，就像低BMD一样。Less（低）

To clarify the etiology of spinal and hip fractures complicated with osteoporosis, the bone mineral density (BMD) and bone geometry or bone metabolic state were studied.The BMDs were measured with dual-energy X-ray absorptiometry (DXA) equipment ; the DCS-600 for midradius, and the QDR-2000 for the second to fourth lumbar vertebrae, and proximal femur. As bone markers, The levels of pyridinoline (Pyr), deoxypyridinoline (D-Pyr), and NTx were measured. This study was conducted on women. Spinal fracture was judged by employing the diagnostic criteria for primary osteoporosis, after morphometry of anterior, central, and posterior vertebral height on lateral X-ray films of the thoracic and lumbar spines. For the geometry of the proximal femur, femur axis length (FAL) and neck width were measured.With respect to spinal fracture ; (1) The radial, lumbar, and femoral BMDs in the fractured cases (N=41) were significantly lower (p<0.0001-0.0062) than those in the non-fractured cases (N=118-125) … More . (2) Pyr levels in the fractured cases tended to be higher. (3) The fractured cases showed a significantly (p=0.0092-0.0188) higher incidence of not only increased levels of both Pyr and D-Pyr (more than 33.2 pmol/mmol/Cr and 6.4 pmol/mmol/Cr, respectively), but also decreased BMD levels, less than 70% of the young adult mean, in both the radius and lumbar vertebrae, compared with the non-fractured cases.With respect to hip fracture ; (1) Femoral neck BMDs were significantly lower(p<0.0001) in the fractured cases (N=76). (2) The increased odds ratio of hip fracture, which is calculated from logistic regression analysis, ageadjusted, was 3.40 (p<0.0001) for a decrease in the ISD of femoral neck BMD, and 1.48 (p=0.0320) for a decrease of 10kg of body weight. (3) The threshold value of femoral neck BMD of hip fractures was 0.516 g/cmィイD12ィエD1, and (4) from a study of fractured cases (N37) and non-fractured cases (N=161) of more than 70 years old, a significantly longer neck width was noted in the fractured cases than in the non-fractured cases, while there were no differences in FAL between the two groups.Thus, it was suspected that spinal fracture is related to both a low BMD and the increased bone turnover, but hip fracture is related to geometry, as well as a low BMD. Less