Study of mechanism of action of antipsychotic drugs in the animal model of schizophrenia

非竞争性NMDA受体拮抗剂蛋白酶（PCP）对多巴胺D-22-D2和血清素5-HT-D22 A-D2受体在大鼠链球菌和前皮质激素中进行了研究，对此，有必要。Neither acute or 3-week treatment with 5 mg/kg PCP had any significant effect on D22-D2 and 5-HT-D22A-D2 receptors。急性或8天休克压力（1系列： 2.5毫安，30秒，随机间隔;平均30秒， 30次）治疗大鼠D2和5-HT D22 A D2受体在两种盐水和五氯苯酚（5毫克/千克）中并不明显影响D2和5-HT D2受体。However， stress-induced changes in the D22 yeD2 and 5-HT yeD22A yeD2 receptors were different， although not significantly， between the两个群体。五氯苯酚治疗可能会影响多巴胺和血清激素治疗系统对压力产生压力，3周治疗与典型抗精神药物氯丙嗪和三种典型抗精神药物（risperidone、olanzapine和perospirone）的影响对D22 ... More D2 and 5-HT D22A D2 receptors were examined in the rat streatum and frontal cortex， respectively。氯丙嗪（10 mg/kg）和帕吡酮（1 mg/kg）明显增加D22和D2受体时，即使没有较低剂量的氯丙嗪（5 mg/kg）、帕吡酮（0.1 mg/kg）、双吡酮（0.25、0.5 mg/kg）或olanzapine （1、2 mg/kg）的亚氯丙嗪（1、2 mg/kg）。对其他手，3周管理氯丙嗪（5， 10 mg/kg）和奥兰扎平（1， 2 mg/kg）明显减少5-HT-D22 A-D2受体，但风险酮（0.25， 0.5 mg/kg）或催乳酮（0.1， 1 mg/kg）没有效果。The measurement of in vivo Drug occupation for D22 D2 and 5-HT D22A受体using N-ethoxycarbony1- 2-ethoxy-1，2-dihydroquinoline（EEDQ） suggested that high occupation of 5-HT-D22A-D2 receptors with lower D22-receptor occupancy might be involved in the absence of up-regulation of D22エD2 receptors after subManagement treatment with some atypical antipsychotic drugs。Less（低）

The effect of non-competitive NMDA receptor antagonist phencyclidine (PCP) on the binding to dopamine DィイD22ィエD2 and serotonin 5-HTィイD22AィエD2 receptor was examined in the rat striatum and frontal cortex, respectively. Neither acute or 3-week treatment with 5 mg/kg PCP had any significant effect on DィイD22ィエD2 and 5-HTィイD22AィエD2 receptors. Acute or 8-day footshock stress (1 series: 2.5 mA for 30 sec, randam interval; mean 30 sec, 30 times) did not significantly affect the D2 and 5-HTィイD22AィエD2 receptors in both saline- and PCP (5 mg/kg)-treated rats. However, stress-induced changes in the DィイD22ィエD2 and 5-HTィイD22AィエD2receptors were different, although not significantly, between the two groups. It is possible that PCP treatment may influence the dopaminergic and serotonergic compensatory systems to stress.The effects of 3-week treatment with a atypical antipsychotic drug chlorpromazine and three typical antipsychotic drugs (risperidone, olanzapine and perospirone) on the binding to DィイD22 … More ィエD2 and 5-HTィイD22AィエD2 receptors were examined in the rat striatum and frontal cortex, respectively. Subchronic treatment with chlorpromazine (10 mg/kg) and perospirone (1 mg/kg) significantly increased DィイD22ィエD2 receptors, while no increase was observed with lower dose of chlorpromazine (5 mg/kg), perospirone (0.1 mg/kg), risperidone (0.25, 0.5 mg/kg) or olanzapine (1, 2 mg/kg). On the other hand, 3-week administration of chlorpromazine (5, 10 mg/kg)and olanzapine (1, 2 mg/kg) significantly decreased 5-HTィイD22AィエD2 receptors, but risperidone (0.25, 0.5 mg/kg) or perospirone (0.1, 1 mg/kg) had no effect. The measurement of in vivo drug occupation for DィイD22ィエD2 and 5-HTィイD22AィエD2 receptors using N-ethoxycarbony1-2-ethoxy-1, 2-dihydroquinoline (EEDQ) suggested that high occupation of 5-HTィイD22AィエD2 receptors with lower DィイD22ィエD2 receptor occupancy might be involved in the absence of up-regulation of DィイD22ィエD2 receptors after subchronic treatment with some atypical antipsychotic drugs. Less