Development of ultra-fast funcional MRI

血氧水平依赖性（BOLD）对比功能磁共振成像（MRI）已经彻底改变了人类大脑高级功能的研究。然而，该方法仍然具有各种缺点。与流行的看法相反，BOLD-fMRI在目前的形式不具备足够的有效性，关于时间分辨率。该项目旨在进一步完善BOLD-fMRI技术，利用高场（3.OT）系统，特别是在时间分辨率方面。本项目的技术成果包括：（1）BOLD-fMRI水平3.0T系统的优化;（2）垂直3.0T系统开发所需的各项关键技术的实现;（3）fMRI与高密度（256通道）脑电地形图的同步分析。该项目还产生了各种神经科学发现，包括发现运动前无运动区，人类在三维视觉信息处理中的右半球优势，以及精神分裂症患者在工作记忆任务中缺乏适当的背外侧额叶激活。

Blood oxygenation level dependent (BOLD) contrast functional magnetic resonance imaging (MRI) has revolutionized the investigations of higher brain function in humans. Nevertheless, the method still has various shortcomings. Contrary to popular belief, BOLD-fMRI in the current form does not possess sufficient validity regarding temporal resolution. The projects are designed to further refine the BOLD-fMRI technique utilizing a high-field (3.OT) system, especially in the aspect of temporal resolution. Technical achievements of the project include (1) optimization of horizontal 3.0T system for BOLD-fMRI, (2) realization of various critical technologies necessary in the development of a vertical 3.0T system, and (3) synchronized analysis of fMRI and high-density (256 channel) EEG topography. The project has also yielded various neuroscientific findings, including the discovery of a premotor no-motion area, right hemisphere dominance in 3 dimensional visual information processing in humans, and lack of appropriate dorsolateral frontal lobe activation in schizophrenic patients during a working memory task.