FOR 1186: Photorespiration: Origins and Metabolic Integration in Interacting Compartments

光呼吸是植物初级代谢的主要途径之一。就质量流而言，它仅次于光合作用，实际上构成了陆地生物圈中第二重要的过程。相关的二氧化碳损失可能非常高，并且由于气温升高和干旱而进一步增加，从而降低了重要作物的产量。鉴于这一过程对植物代谢、适应和生产力的重要性，以及新工具的显著推动，研究单位解决了光呼吸代谢的起源、代谢整合和细胞生物学等主要未解决的问题。为此，十个研究小组和相关伙伴的多价值专业知识以及先进的技术平台将结合起来，寻求两种新方法。系统生物学方法将提供对光呼吸各组成部分之间发生的动态相互作用的全面理解，以便将系统视为一个整体并允许定量预测。与此相辅相成的是，综合合成生物学方法促进可持续能源生产的植物育种。

Photorespiration represents one of the major highways of plant primary metabolism. By mass flow, excelled only by photosynthesis, it actually constitutes the second-most important process in the land-based biosphere. Related CO2 losses can be very high and are further elevated by warmer temperatures and drought, hence reducing the yields of important crops. In light of the importance of this process for plant metabolism, adaptation and productivity, and significantly boosted by new tools, the Research Unit addresses major unresolved questions of the origins, metabolic integration and cellular biology of photorespiratory metabolism. To this end, the multivalent expertise of ten research groups and associated partners as well as advanced technology platforms will be combined to pursue two new approaches. A systems biology approach will provide a comprehensive understanding of the dynamic interactions that take place between the components of photorespiration in order to appreciate the system as a whole and allow quantitative predictions. Complementary to this, an integrated synthetic biology approach promotes plant breeding for sustainable energy production.