Molecular bases of the body-plan in vertebrate

Hox基因在位置特定标记与肢体网格细胞交互和表达配置文件中显示的闭合关系与跟随肌肉质量分离模式62表达在Tendon预光标细胞下的信号控制下的信号来自肢体纹理和ectoderm。在添加Hox蛋白质调制这些信号的敏感性。（A.K.）Transcription factor SOX 2/SOX 3 and PAX6 were expressed in the lens placode during and functioned through interacting with enhancer DC5 of crystalline gene。这些转录因子被定义为透镜的位置差异在一个组合的标记中，当它被描述为在embryos中。（香港）我们研究了通过对功能的分析和对ascidian homeobox基因表达的规则的建立过程。我们发现了Otx刺激差异，使其朝着外部神经系统和控制下游基因作为转录激活器的表达方式。（H.S.）小鼠小说基因mmabl，一个nematode mab 21的orthologs，及其同源mmab 2被隔离为下游目标基因的Hoxc-4。我们制造了这些基因的老鼠，并发现了mmab 1在睾丸中的表达在Hoxc-4的控制之下。（不，T）STEF，一个仍然存在的Drosophila的小鼠同源物，是一个Rac特定的Guanine核苷酸交换因子。STEF在细胞酮系统的适应性变化下，通过Rac激活了迁移、轴向扩展和综合形成。（Y.N.）根据Drosophila的相互分析，我们发现基因确定了一种新颖的和进化的蛋白质的身体大小。遗传相互作用实验揭示了蛋白质产品在胰岛素受体系统中功能良好的E2 A上游，以控制细胞生长。（Y.N.）

Hox genes are expressed in the limb muscle precursor in position specific manner by interacting with the limb mesenchymal cells and the expression profile exhibited closed relationship with following muscle mass splitting pattern Six2 expression in the tendon precursor cells was under the control of the signals from the limb cartilage and the ectoderm. In addition Hox protein modulated the sensitivity for these signals. (A.K.) Transcription factor SOX2/SOX3 and PAX6 were expressed in the lens placode during development and functioned through interacting with enhancer DC5 of ヲト-crystalline gene. These transcription factors induced lens placode differentiation in a combinational manner when ectopically expressed in the embryos. (H.K.)We examined the process of the establishment of vertebrate body plan through the analysis of the function and the regulation of the expression of the ascidian homeobox genes. We found that Otx stimulates differentiation toward anterior nervous system and controls the expression of the downstream genes as the transcriptional activator. (H.S.) Mouse novel gene mmabl, a ortholog of nematode mab21, and its homolog mmab2 were isolated as the downstream target gene of Hoxc-4. We produced knockout mice of these genes and found that the expression of mmab1 in the sternum was under the control of Hoxc-4.(N.T.) STEF, a mouse homolog of Drosophila still life, is a Rac specific guanine nucleotide exchanging factor. STEF was involved in the migration, axonal extension and synapse formation through activation of Rac followed by the conformational change of the cytoskeleton system. (Y.N.) By Drosophila mutational analysis, we found the gene determining the body size that encodes a novel and evolutionary conserved protein. Genetic interaction experiment revealed that the protein products functioned upstream of E2A in the Insulin receptor system that control cellular growth. (Y.N.)