Parietal epithelial cell activation and glomerulosclerosis: Mechanisms, mediators and clinical diagnosis ((3)-P17)

基于我们第一个资助期的进展，我们将研究肾小球高滤过和肾小球肥大作为壁细胞（PEC）激活和诱导肾小球硬化（FSGS）的独立危险因素的分子和生物物理机制。为了提高诊断，我们将分别在肾活检和尿液中识别和表征PEC激活和单肾单位肾小球滤过率（SNGFR）的新生物标志物。最后，我们和其他人在新生哺乳动物的鲍曼囊上发现了一个额外的足细胞储存库。我们将研究足细胞的募集是否受到调控以及是否可以增强。

Building on our progress from the first funding periods, we will investigate the molecular and biophysical mechanism of glomerular hyperfiltration and glomerular hypertrophy as independent risk factors for parietal cell (PEC) activation and induction of glomerulosclerosis (FSGS). To improve diagnosis, we will identify and characterize novel biomarkers for PEC activation and single nephron glomerular filtration rate (SNGFR) in renal biopsies and in urine, respectively. Finally, we and others have identified an additional reservoir of podocytes on Bowman's capsule in newborn mammals. We will investigate whether recruitment of podocytes from this reservoir is regulated and whether it can be enhanced.