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Study of childhood leukemia after Chernobyl

Study of childhood leukemia after Chernobyl
切尔诺贝利事故后儿童白血病的研究
批准号:
09041178
负责人:
KOIKE Kenichi
金额:
$3.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B).
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1999

项目摘要

项目成果

KOIKE Kenichi的其他基金

相关文献

中文摘要
翻译
自1945年以来发生的23起辐射事故,1986年4月26日在乌克兰切尔诺贝利核电站发生的事故,已经产生了受害者人数最多的。根据国际原子能机构的数据,从受污染的白俄罗斯和俄罗斯的损坏单元释放了放射性气体和气溶胶,如乌克兰所示。The Gomel region in Belarus received a high level of fallout containing D1137 d1Cs.大多数放射性细胞的寿命很长,并被该地区的原住民所污染。放射性疾病在不同的延迟期内导致各种癌症类型;这些癌症包括白血病、甲状腺癌和乳腺癌。Kazarkov等人报告了白俄罗斯儿童中甲状腺癌频率的显著增加,在Gomel地区的某些人, 1990年,我们进行了一次临床调查,以确定内部暴露到长期放射性辐射影响了Leukemia的分布情况。在目前的研究、类型和实验室中 ... More 我发现了一个与莱克米亚的孩子在受感染的情况之间是比较的。白俄罗斯的地区(戈梅尔地区)和非受污染地区(维特布斯克地区)。急性淋巴瘤白血病患者的频率(所有)在这两个地区并不不同。在对比度下,慢性骨髓性白血病患者的百分比(CML)在戈梅尔出现更高的整个白血病患者的百分比,但这在统计上并不重要。在所有患者的一集中,年轻患者的相对人数(0至2岁)在Vitebsk比Gomel大(35%对.14%, p=0.0086)。LDH升高的患者比率(>500 IU/L)也有不同; Gomel为68.8%,Vitebsk为37.8%。在这两个群体中,在瘦骨细胞计数、红细胞蛋白水平和平台计数之间没有区别。因此,这些结果显示,白血病患者生活在受污染的地区,由于放射性化合物的混合物与他们在非受污染的地区的临床发现不同。Less(低)
英文摘要
Of 23 radiation accidents that have occurred since 1945, the accident at the Chernobyl Nuclear Power Station in Ukraine, on 26 April 1986, has generated the largest number of victims. According to the International Atomic Agency, radioactive gases and aerosols released from the damage unit contaminated Belarus and Russia, as well as Ukraine. The Gomel region in Belarus received a high level of fallout containing ィイD1137ィエD1Cs. Most of the radionuclides are long-lived and have contaminated the inhabitants of this area. Radiation disasters induce various types of cancers with different latency periods; these cancers include leukemia and thyroid and breast cancer. Kazarkov et al. reported a marked increase in the frequency of thyoid cancer in children in Belarus, in particular those in the Gomel region, 1990.We performed a clinical survey to determine whether internal exposure to the long-lived radionuclide influenced the occurrence of leukemia. In the present study, the types and laborat … More ory findings of children with leukemia were compared between the contaminated. area (Gomel region) and non-contaminated area (Vitebsk region) in Belarus. The frequency of patients with acute lymphoblastic leukemia (ALL) was not different in the two areas. In contrast, the percentage of patients with chronic myelogenous leukemia (CML) among whole leukemia patients appeared to be higher in Gomel, but it was not statistically significant. At the onset of ALL patients, the relative number of younger patients (0 to 2 years old) was substanitially greater in Gomel than in Vitebsk (35% vs. 14%, p=0.0086). The ratio of the patients with elevated level of LDH (>500 IU/L) was also different; 68.8% in Gomel and 37.8% in Vitebsk. However, there was no difference in leukocyte count, hemoglobin level and platelet count between the two groups. Thus, these results showed that leukemia patients living in areas contaminated with a mixture of radionuclides have clinical findings different from those in non-contaminated area. Less
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Sawai N, Koike K, et al.: "Neutrophilic cell production by combination of SCF and TPO from CD34+ CB cells in long-term serum-deprived liquid culture."Blood. 91. 509-518 (1999)
Sawai N、Koike K 等人:“在长期去血清液体培养物中,通过结合 SCF 和 TPO 从 CD34 CB 细胞中产生中性粒细胞。”血液。
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通讯作者:
Takeuchi K,Koike K,et al: "Chemoking production by human megakaryocytes derived from CD34-positive cord blood cells." CYTOKINE,in press.
Takeuchi K、Koike K 等人:“源自 CD34 阳性脐带血细胞的人类巨核细胞产生化疗。”
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通讯作者:
Saawai N, Koike K, et al.: "Neutrophilic cell production by combination of SCF and TPO from CD34+cord blood cells in long-term serum-deprived liquid culture."Blood. 93. 509-518 (1999)
Saawai N、Koike K 等人:“在长期去血清液体培养物中,通过结合 SCF 和 TPO 从 CD34 脐带血细胞中产生中性粒细胞。”血液。
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通讯作者:
T Higuchi, Koike, et al.: "Megakaryocytes derived from CD34-positive cord blood cells produce interleukin-8" BrJ Haematol. 99. 509-516 (1997)
T Higuchi、Koike 等人:“源自 CD34 阳性脐带血细胞的巨核细胞产生白细胞介素 8” BrJ Haematol。
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共 18 条
    Establishment of T lymphocytes expressing chimeric antigen receptor for leukemic stem cells
    • 批准号:
      24390260
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.4万
    • 财政年份:
      2012
    • 负责人:
      KOIKE Kenichi
    • 依托单位:
    Analysis of pathogenesis of refractory childhood myelodysplastic syndrome using disease-specific iPS cells
    • 批准号:
      21390308
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.4万
    • 财政年份:
      2009
    • 负责人:
      KOIKE Kenichi
    • 依托单位:
    Epigenetic regulation of proliferation and differentiation of hematopoietic stem cells
    • 批准号:
      17390300
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.65万
    • 财政年份:
      2005
    • 负责人:
      KOIKE Kenichi
    • 依托单位:
    Epigenetic regulation of p15 mRNA expression in juvenile myelomonocytic
    • 批准号:
      15591099
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.37万
    • 财政年份:
      2003
    • 负责人:
      KOIKE Kenichi
    • 依托单位: