THE MATERNAL GUT MICROBIOTA DRIVES FOETAL THYMIC T CELL DEVELOPMENT

本项目旨在研究母体肠道菌群对胎儿免疫发育的作用，揭示新生儿早期肠道菌群与宿主免疫的相互作用。值得注意的是，这项研究将检查母亲微生物群副产物到达胎儿并影响免疫力发育的时间窗口。母体副产品将使用尖端的方法来确定，以解开复杂的系统在发展过程中的相互作用。成果包括关于母体肠道微生物群组成及其与生长中的胎儿的关系的新的基本知识，有益于告知孕妇她们在怀孕期间的生活方式选择，特别是她们的饮食习惯。

This project aims to investigate the role of maternal gut microbiota on foetal immune development, revealing the interaction of gut microbiota-host immunity at the early stages of new life. Significantly, the research will examine the time window when microbiota by-products from the mother reach the foetus and affect the development of immunity. Maternal by-products will be identified using cutting-edge methods to unravel the complex systems interactions in the developmental process. Outcomes include new fundamental knowledge about maternal gut microbiota composition and its relationship to the growing foetus, with benefits in informing pregnant women about their lifestyle choices, particularly their dietary habits, during pregnancy.