The relationship between maternal and infant dietary intake of fermentable fibre, gut microbiota, short chain fatty acids and allergic disease and asthma: a population-derived birth cohort study

母婴膳食中可发酵纤维、肠道微生物群、短链脂肪酸的摄入量与过敏性疾病和哮喘之间的关系：一项源自人群的出生队列研究

• 批准号: nhmrc : GNT1082307
• 负责人: Dr Michael Conlon
• 金额: $ 84.37万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/relationship-maternal-infant-cohort-study/1345452
• 关键词: relationship; between; maternal; infant; dietary

The proposed study will involve the Barwon Infant Study (BIS) cohort of 1074 infants to provide the first systematic investigation of the hypotheses that the epidemic of allergic disease and asthma in many parts of the world relates to the paucity of fermentable fibre in the modern diet, and that the protective effect of fermentable fibre is mediated by changes in the organisms that colonise the gut and the metabolites that they produce.

这项拟议的研究将涉及1074名婴儿的Barwon婴儿研究（BIS）队列，以提供对以下假设的首次系统调查：世界许多地区过敏性疾病和哮喘的流行与现代饮食中可发酵纤维的缺乏有关，并且可发酵纤维的保护作用是通过肠道中的微生物及其产生的代谢物的变化来介导的。