Feasibility study for the use of computer game technology in the early diagnosis of Mild-Cognitive-Impairment-Alzheimer’s-Disease

这项研究展示了一个简单的基于网络的在线视频游戏（G:DATA；基于游戏的痴呆症自动测试算法）如何提供一种廉价、易于使用的测试，可以发现阿尔茨海默病的早期迹象，比目前存在的任何测试都要早得多。它使用了精心设计的虚拟环境，玩家必须在其中导航，通过这样做，可以直接评估受阿尔茨海默病影响的第一批脑细胞，这是现有技术无法检测到的。G:DATA旨在提供有效和及时的同步筛查和诊断，可能早在疾病的影响成为患者、其家庭和整个社会的负担之前，就有可能提高患者的生活质量。该项目将努力创建一个可玩的G:DATA版本，并在临床环境中对患有早期和晚期阿尔茨海默病的患者以及健康人群进行测试，以证明G:DATA有效，可以有效地筛选、诊断和区分这些患者群体。该项目将使Ascentys能够获得必要的信息，以确保：* G:DATA可以很容易地被其目标患者使用*如何最好地利用G:DATA来确保在现有的NHS途径中产生积极的破坏性影响，从而大大提高阿尔茨海默病患者筛查和诊断以及潜在疾病进展监测的有效性和效率。这一智能应用程序使Ascentys能够获得探索这一概念可行性所需的关键专业知识和设施，我们的联盟包括：*杜伦大学；神经科学专业知识;* Hywel Dda医院信托；临床专业知识和获得患者志愿者、法规遵从性和卫生经济学见解；* Medipex（分包商）；知识产权保护专业知识。该项目具有高度创新性，因为现有的筛查和诊断阿尔茨海默病的方法在临床时间、精力、负担和复杂性（需要多次测试）方面都是高度资源密集型和昂贵的。对于患者来说，这些检查也是高度侵入性的（脊髓穿刺、血液、PET和MRI扫描），显然令人望而生畏，而且从最初的全科医生筛查到最终的医院诊断，等待名单要长得多。我们提出的G:DATA游戏弥补了上述所有缺点，提供了一种更快速、更便宜、更方便的替代方案，旨在大大减少临床医生的时间，提高有效筛查和诊断的可及性，识别需要及时护理的大规模患者。G:DATA有可能成为一种高度出口的英国开发的解决方案，改变阿尔茨海默病在全国乃至更远的治疗途径，重要的是，它也是开发一种突破性的有效治疗方法的第一步。

This research demonstrates how a simple online web-based videogame (G:DATA; Game based Dementia Automated Test Algorithm) may provide an inexpensive, easy-to-use test that can spot the earliest signs of Alzheimer's Disease, well in advance of anything that currently exists.It uses carefully designed virtual environments that a player must navigate and by doing so directly assesses the first brain cells that are affected by Alzheimer's Disease, undetectable by existing techniques.G:DATA is designed to provide effective and timely concurrent screening and diagnostics, perhaps long before the effects of the disease become a burden to the patient, their family and society as whole, potentially increasing patient quality of life.This project will endeavour to create a playable version of G:DATA and test it with patients that have early and late-stage Alzheimer's Disease alongside healthy people in a clinical setting to prove G:DATA works and can effectively screen, diagnose and distinguish between these patient groups.The project will allow Ascentys to gain essential information to ensure:* G:DATA can be easily used by its intended patients* How G:DATA can be best used to ensure positive disruptive impact within existing NHS pathways to greatly raise effectiveness and efficiency of both screening and diagnosis for Alzheimer's patients and potential disease progression monitoring.This Smart application enables Ascentys to access crucial expertise and facilities needed to explore the feasibility of this concept, our consortium comprises of:* Durham University; Neuroscientific expertise;* Hywel Dda Hospitals Trust; Clinical expertise and access to patient volunteers, regulatory compliance and health economics insight;* Medipex (subcontractor); IP protection expertise.The project is highly innovative because existing methods of screening and diagnosing Alzheimer's-Disease are highly resource intensive and expensive in terms of clinical time, effort, burden and complexity (need for multiple tests). For the patients these tests are also highly invasive (Spinal puncture, blood, PET and MRI scans), obviously daunting and suffer from a substantially growing waiting list between initial GP screening and eventual hospital diagnosis.Our proposed G:DATA game remedies all of the shortcomings described above, providing a vastly more rapid, cheaper and convenient alternative, designed to greatly reduce clinician time and enhance accessibility to effective screening and diagnosis, identifying patients at scale needing timely care.G:DATA could potentially be a highly exportable UK developed solution transforming the Alzheimer's Disease care pathway landscape nationally and beyond for this horrendous condition and importantly also a first step in developing a ground-breaking effective treatment.