Continuation of manufacturing operations during Covid-19 restrictions by additional site rental

该Eurostars项目的目的是通过为外科医生提供安全，快速和高效的解剖结构3D打印（3DP）来改善骨外科护理。3D模型对于复杂骨手术的手术规划很有价值，可以预先安装接骨板和螺钉，并优化手术方法。因此，3D模型减少了手术时间、失血量、组织损伤和并发症风险，从而改善了手术结果并加快了患者康复。当前基于骨的3DP的计算机断层扫描（CT）是昂贵、费力和耗时的，并且不能包括骨周围的软组织结构。此外，CT成像基于有害辐射。在OPERATE项目中，将基于联盟合作伙伴UMC Utrecht（UMCU）和MRIguidance（MG）开发的专有骨磁共振成像（Bone MRI）技术开发3DP端到端解决方案。这是第一种用于无辐射骨成像的技术，同时也是第一种用于骨和周围软组织表征的技术。它将与Axial3D（Axial）的技术相结合，用于将医学图像自动转换为3D打印文件。UMCU将确保获得临床专业知识和患者数据。该项目的结果将是一个快速，无辐射和高效的端到端解决方案，用于骨外科应用的3DP。3D模型的几何精度将通过与最先进技术的比较来确认。OPERATE端到端解决方案将提供给骨外科医生，用于生成受损伤或癌症影响的骨和软组织结构的解剖模型，用于优化个性化手术计划。OPERATE解决方案将提供给欧盟提供骨外科手术的医院，并随后推向全球市场。在项目结束后的5年内，累计收入估计为2700万欧元，来自向该联盟广泛的临床网络提供的软件许可销售和服务，以及通过主要医疗成像和3DP硬件供应商的间接分销。

The aim of this Eurostars project is to improve bone surgical care, by providing surgeons with access to safe, fast and efficient 3D printing (3DP) of anatomical structures for surgery planning. 3D models are valuable for surgery planning of complex bone surgeries, allowing for pre-fitting of plates and screws and to optimize a surgical approach. As such, 3D models reduce operative time, blood loss, tissue damage and complication risk, leading to improved surgical outcomes and faster patient recovery. Current computed tomography (CT) based 3DP of bones is costly, laborious and time-consuming, and is unable to include the soft tissue structures surrounding the bone. Moreover, CT imaging is based on harmful radiation. Because of these limitations, the broad clinical adoption of 3DP as a tool to improve bone healthcare has been slow.In the OPERATE project a 3DP end-to-end solution will be developed based on the proprietary Bone Magnetic resonance imaging (Bone MRI) technology developed by consortium partners UMC Utrecht (UMCU) and MRIguidance (MG). This is the first technique for radiation-free bone imaging, as well as for characterization of bone and surrounding soft tissue at the same time. It will be combined with Axial3D (Axial)'s technology for automated conversion of medical images to 3D printable files. UMCU will ensure access to clinical expertise and patient data.The project result will be a fast, radiation-free and efficient end-to-end solution for 3DP for bone surgery applications. The geometrical accuracy of 3D models will be confirmed by comparison to state-of-the-art technologies. The OPERATE end-to-end solution will be offered to bone surgeons for the generation of anatomical models of bone and soft tissue structures affected by injury or cancer, to be used for optimal personalised surgical planning.The OPERATE solution will be offered to hospitals providing bone surgery in the EU and subsequently to global markets. Cumulative revenues of €27 million are estimated within 5 years after project end, coming from software license sales and service offerings to the consortium's extensive clinical network and indirect distribution through main medical imaging and 3DP hardware vendors.