Colon Kit: Feasibility assessment of production scale-up for an integrated model of the human large intestine

该项目旨在评估扩大“结肠试剂盒”生产的可行性，这是一种人类大肠的研究模型。这将满足为研究和个性化医疗提供有效和负担得起的人类大肠模型的迫切需求。该产品可以为实验室提供一种方便、负担得起的前沿研究工具。该产品还具有诊断和预后的潜力。该工具可用于开展针对患者的调查和治疗筛选，以更好地确定有效的治疗方法。人类微生物组市场价值为3.763亿美元（2019年），2020年至2027年的复合年增长率为21.8% （VMR， 2019年）。微生物组对健康和疾病的重要性日益得到认识，健康和制药产品的开发旨在满足这一需求。Aelius生物技术吗?是一家专门研究消化道实验室模型的研究机构，提供一系列研究工具来帮助理解和开发配方，以改进和降低产品开发的风险，并将成功的产品推向市场。Aelius已经开发并测试了一个早期的原型集成大肠模型，这是同类模型中的第一个，包括一个细胞培养系统，该系统集成了肠道黏液双层和上皮与微生物组的建模。这有可能是消化建模的一个巨大发展，提供了第一个能够在从口腔到末端大肠的连续集成系统中模拟消化的管腔，粘液和上皮阶段的系统。这个项目的目的是让全球的研究实验室都能使用这项技术。这个可行性项目将利用CPI在“设计制造”方面的专业知识。CPI作为高价值制造弹射器的一部分，将调查设计和制造选项的可行性，并与当前最先进的技术进行试验和比较，以确保该设备满足行业需求，可用且可被用户接受，从而增加客户采用的可能性。该项目包括用商业产品验证模型，以生成案例研究和验证数据，以推广模型。

This project aims to assess the feasibility of scaling up production of a 'Colon Kit' a research model of the human large intestine. This will meet the pressing need for effective and affordable models of the human large intestine for research and personalised medicine.This product can provide an accessible, and affordable cutting edge research tool for labs. The product also has diagnostic and prognostic potential. The tool can be used to carry out patient specific investigations and treatment screens to better identify effective treatments.The Human Microbiome Market is valued at $376.3 Million (2019) with CAGR of 21.8% from 2020 to 2027 (VMR, 2019). The importance of the microbiome to health and disease is increasingly recognised, and health and pharmaceutical product development aims to address this need.Aelius Biotech?are a research organisation who specialise in lab models of the digestive tract, offering a range of research tools to help understand and develop formulations to improve and de-risk product development and get successful products to market.Aelius has developed and tested an early-stage prototype integrated large intestinal model -- the first of its kind that includes a cell culture system that integrates modelling of the intestinal mucus bi-layer and epithelium with the microbiome. This has potential to be a huge development in digestive modelling providing the first system capable of modelling luminal, mucus and epithelial phases of digestion in a continuous, integrated system from mouth to terminal large intestine. This project aims to make this technology accessible globally to research labs.This proposed feasibility project would draw on the expertise of CPI in 'design for manufacture'. CPI as part of the High Value Manufacturing Catapult will investigate feasibility of design and manufacturing options, trial and comparison to current state-of-the art to ensure that the device meets industry needs, is usable and is acceptable to users, thereby increasing the likelihood of adoption by customers.The project includes validation of the model with commercial products to generate case studies and validation data to promote the model.