Mechanisms and Platforms for Acoustomicrofluidic Intracellular Delivery

该项目旨在推进一种新的平台，以促进分子更快、更有效地进入细胞，作为加强细胞工程的一种手段。除了通过理论建模、先进成像和中子衍射相结合的方式阐明这种新的细胞内传输方法的基本物理、化学和生物机制外，该项目还旨在展示高通量处理技术的可扩展性，以处理剂量在实践中有效通常所需的大量细胞。鉴于最近细胞疗法的突破，预计从长远来看，这项技术的转化将改善癌症和其他传染病的治疗。

This project aims to advance a novel platform to facilitate faster and more effective molecular transport into cells as a means for enhancing cell engineering. Besides elucidating the fundamental physicochemical and biological mechanisms underpinning this new method of intracellular transport through a combination of theoretical modelling and advanced imaging and neutron diffraction, the project aims to show the scalability of the technology for high throughput processing to handle the large cell numbers typically required for doses to be effective in practice. Given recent breakthroughs in cell therapies, it is expected that translation of the technology in the longer term will improve treatments for cancer and other infectious diseases.