NRSA Training Core

摘要 斯克里普斯翻译科学学院(STSI)TL1培训计划的目标是为博士后和博士后提供 研究员在前沿方法和分析方法方面具有独特的经验，旨在使他们在 翻译和精准医学的复杂领域。该计划隶属于基础研究机构，而不是 医学院通过提供基础研究、药物发现和教育，使其具有独特的地位和优势 发展、临床前模型和对疾病的机械性洞察。非常强调团队科学和 将来自斯克里普斯健康中心的主治医生整合到所有项目中，该计划将培养出具有技能的领导者 需要进行变革性的翻译科学。到目前为止，这个年轻的项目只培养了博士前研究员。 所有8名毕业生，在此过程中发表了31篇论文，都留在了理工科，6名学生仍然得到支持 通过程序。在这一成功的基础上，并在彻底分析了在高效交付方面仍然存在哪些瓶颈之后 翻译研究，我们将通过实现3个具体目标来实施一系列更改以增强我们的计划： 具体目标1.扩展当前的课程，以提供尖端的临床翻译研究能力，以及 加强导师关系。这一目标将通过增加新的课程来实现，这些课程旨在解决最新的科学 还有医疗问题。将通过在每月会议和演示期间协调每个项目来加强指导 进步的力量。使用已在斯克里普斯研究所(TSRI)广泛使用的个人发展计划 将逐步实施，以提高效率和培训为目标。 具体目标2.扩大当前的TL1方案，以提供成功所需的受训人员的完整代表 临床-翻译项目。除了我们成功的博士后项目，我们还将包括一个为期3年的博士后项目 在完成博士学位之后增加翻译能力的途径。为了实现这一目标，培训上的槽数 助学金将增加到9。由TSRI研究生院支持的暑期本科生研究实习生也将 在该计划内提供指导，以便在所有级别的培训中增加翻译能力。一个更具包容性的TL1计划将 激励处于各个发展阶段的科学家从事转化性临床研究。 具体目标3.增加我们培训计划的多样性。精准医学的实现离不开急诊 对多样性的认知。我们的目标将是增加我们项目中代表人数不足的学生的数量 通过增加与服务于这些人群的大学和研究生院的招聘关系。正在进行的夏季研究 秉承这一理念的实习项目在TSRI和STSI非常成功。此外，我们将扩大这一点 通过与特定疾病倡导组织建立关系，作出必要的努力。 该计划的这些变化和演变来得正是时候，TSRI有两个令人兴奋的发展： 整合加州生物医学研究所(CALIBR)，这是一个药物发现和开发研究所， 将允许在该领域培训TL1学生，并在2018年创建一所斯克里普斯研究生物科学学院。

Abstract The objective of the Scripps Translational Science Institute (STSI) TL1 training program is to give pre- and postdoctoral fellows a unique experience in cutting-edge methodological and analytical approaches aimed at making them efficient in the complex arena of translational and precision medicine. This program’s affiliation to a basic research institute instead of a medical school gives it a unique position and strength by offering education in basic research, drug discovery and development, preclinical models, and mechanistic insights into diseases. With a strong emphasis on team science and the integration of attending physicians from Scripps Health in all projects, this program will produce leaders with the skills required to conduct transformative translational science. To date, this young program has trained only predoctoral fellows. All 8 who have graduated, publishing 31 papers in the process, have remained in science, and 6 students remain supported by the program. Based on this success, and after thorough analysis of what bottlenecks remain in the delivery of efficient translational research, we will implement a series of changes to enhance our program by carrying out 3 specific aims: Specific Aim 1. Expand the current coursework to deliver cutting-edge clinical-translational research competencies, and enhance mentorship. This objective will be achieved by adding new courses aimed at addressing the most current scientific and medical issues. Mentorship will be reinforced by coordinating each project around monthly meetings with presentation of progress. The use of Individual Development Plans, already widely used at The Scripps Research Institute (TSRI) Graduate School, will be progressively implemented with the goal of improving efficiency and training. Specific Aim 2. Expand the current TL1 program to provide the full representation of trainees necessary for successful clinical-translational projects. In addition to our successful predoctoral program, we will include a 3-year postdoctoral pathway to add translational competencies beyond PhD completion. To achieve this goal, the number of slots on the training grant will be increased to 9. Summer undergraduate research interns supported by the TSRI Graduate School will also be mentored within this program to add translational competencies at all levels of training. A more inclusive TL1 program will stimulate scientists at each level of development to pursue careers in translational clinical research. Specific Aim 3. Increase diversity in our training program. Precision medicine cannot be achieved without an acute perception of diversity. Our efforts will be targeted at increasing the number of underrepresented students in our program by adding recruitment relationships with colleges and graduate schools serving these populations. Ongoing summer research internship programs with this philosophy have been highly successful at TSRI and STSI. In addition, we will amplify this necessary effort by establishing relationships with disease-specific advocate organizations. These changes and evolution of the program come at a remarkable time with two exciting developments at TSRI: the integration of the California Institute for Biomedical Research (Calibr) a drug-discovery and development institute that will allow training of TL1 students in that field, and the creation of a Scripps Research Biosciences College in 2018.