Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational Core

摘要 临床和转化核心（临床核心）旨在促进以患者为导向的研究， 研究人员从临床转化研究到人口流行病学。资源和 将在共同的临床核心保护伞下汇集专业知识， 转化研究资源，包括但不限于获得生物样品，技术资源， 样本分析和生物统计支持以及临床数据，同时通过以下方式提高运营效率： 专家知识的建设，实施和解释的研究。主 临床核心的优点是：1）它通过提供先验步骤来提高实验的质量- 明智的设计过程; 2）它通过提供各种临床试验来简化实验限制 研究资源;和3）它包括数据和样本协调和存储的基础设施。的 临床核心将通过建立三个子核心来实现这些目标：1）生物储存子核心; 2）人类 代谢表型亚核心和3）临床流行病学和生物统计学亚核心。内部和 外部用户将通过以下方式访问这些资源：1）直接请求生物样本，包括组织; 2）请求 来自大型队列研究的临床和研究数据，包括BioVU和Research Derivative; 3）要求 为新的、正在进行的或已完成的研究的设计和解释提供统计支持;以及4）请求 分析资源。对于实施和管理，临床核心建议将所有 信息和标本纳入分析，统计和生物信息学服务，从而提高效用 这些资源。临床核心还将协助研究者进行研究交流 将研究结果提供给作为研究过程伙伴的利益攸关方和目标社区成员。在 为了实现这些目标，临床核心将利用现有的机构资源，如 范德比尔特临床和转化研究所（VICTR）、范德比尔特糖尿病研究所和 培训中心（DRTC）和消化疾病研究中心（DDRC）。

ABSTRACT The Clinical and Translational Core (Clinical Core) aims to facilitate patient-oriented research for investigators spanning from clinical translational research to population epidemiology. Resources and expertise will be pooled under the common Clinical Core umbrella to provide a wide range of clinical translational research resources including, but not limited to access to biosamples, technical resources such as sample analysis and biostatistical support and clinical data while increasing the efficiency of operations through expert knowledge for the construction, implementation and interpretation of the studies. The primary advantages of the Clinical Core are that 1) it enhances the quality of the experiments by providing a priori step- wise design process; 2) it alleviates experimental constraints by providing access to a variety of clinical research resources; and 3) it includes an infrastructure for data and sample coordination and storage. The Clinical Core will accomplish these goals by establishing three Subcores: 1) Biorepository Subcore; 2) Human Metabolic Phenotyping Subcore and 3) Clinical Epidemiology and Biostatistics Subcore. The internal and external users will access these resources by: 1) direct requests for biosamples, including tissue; 2) request for clinical and research data from large cohort studies, including BioVU and Research Derivative; 3) requesting statistical support for design and interpretation of new, ongoing or completed studies; and 4) request for analytical resources. For implementation and administration, the Clinical Core proposes to channel all information and specimens into analytical, statistical, and bioinformatics services, thereby enhancing the utility of these resources. The Clinical Core will also assist investigators in the process of communicating research findings to stakeholders and members of target communities that are partners in the research process. In accomplishing the goals, the Clinical Core will take advantage of available institutional resources, such as the Vanderbilt Institute for Clinical and Translational Research (VICTR), Vanderbilt Diabetes Research and Training Center (DRTC) and Digestive Disease Research Center (DDRC).