Centers for AIDS Research (CFAR)

项目总结-杜克艾滋病研究中心（总体） 杜克艾滋病研究中心（CFAR）的主要使命是建立和发展全面的 基础设施支持的研究环境，将有效地促进合作，协调， 在整个杜克艾滋病毒/艾滋病研究界和全国CFAR网络的创新。作为 我们NIH资助的研究基地的增长证明了这一点，现在我们有资格成为第2级CFAR， 竞争性续约申请代表了一种基于我们的成就和经验教训的演变 在前几个融资周期中学到的，利用我们的核心团队之间建立的协同效应， 件.一个坚实的基础是由我们非常成功的试点赠款机制，主要针对早期 阶段调查员，我们同样成功的教师招聘工作，这两个都促进了 更大的性别和种族多样性。我们所有不断发展的支持服务背后的驱动力是一个高度 积极有效的战略规划过程，由我们的执行委员会（EC）领导， 我们的咨询委员会和校内战略合作伙伴。这个高度迭代的过程已经确定了 五个具体目标，以指导CFAR的增长和发展，在未来5年：1）提供全面的 为所有校内艾滋病毒/艾滋病调查人员提供基础设施支持，旨在扩大强有力的校内艾滋病毒/艾滋病调查方案， 针对NIH研究优先事项的学科性、协作性艾滋病毒研究。2)继续发展A 通过早期研究人员的大力支持，培养下一代艾滋病毒/艾滋病研究人员， 从艾滋病毒/艾滋病研究领域以外的知名调查人员参与。3)培养批判性 通过核心与核心之间的互动以及新的和现有的战略伙伴关系的参与实现协同增效。四、 通过实施和支持社区，扩大艾滋病毒/艾滋病研究的相关性、范围和影响 参与和外联。5)进一步加强和支持全球范围内的合作活动 CFAR网络。支持服务将得到加强，从杜克的学校的机构支持， 内科和外科。通过战略规划过程，我们确定了八个优先事项 代表下一个供资周期进一步发展机会的领域。这些措施包括：1） “南部艾滋病毒流行病”; 2）艾滋病毒合并症、合并感染和并发症; 3）潜伏期和根除; 4)健康差异; 5）疫苗设计和评估; 6）心理健康和药物滥用; 7）艾滋病毒 器官政策公平（HOPE）法案;和8）新出现的感染。最后，确保持续的高质量 为了支持校内艾滋病毒/艾滋病调查人员，欧盟委员会制定了一项领导层过渡计划， 格鲁吉亚Tomaras博士和Susanna Naggie博士将担任该机构的主任和联合主任， 分别CFAR期待在杜克内部开发和探索这些及时的机会， 在下一个融资周期中，CFAR网络中的所有资金都将被使用。

PROJECT SUMMARY – Duke Center for AIDS Research (Overall) The principal mission of the Duke Center for AIDS Research (CFAR) is to establish and grow comprehensive infrastructure support for a research environment that will effectively promote collaboration, coordination, and innovation throughout the Duke HIV/AIDS research community and across the national CFAR network. As evidenced by the growth in our NIH-Funded Research Base that now qualifies us as a Tier 2 CFAR, this competitive renewal application represents an evolution that builds upon our accomplishments and lessons learned during the previous funding cycles, taking advantage of the synergies established among our Core components. A solid basis is formed by our highly successful Pilot Grant mechanism, aimed primarily at Early Stage Investigators, and our equally successful faculty recruitment efforts, both of which have facilitated greater gender and racial diversity. The driving force behind all of our evolving support services is a highly active and effective Strategic Planning process, led by our Executive Committee (EC), with valuable input from both our advisory committees and our intramural Strategic Partners. This highly iterative process has identified five Specific Aims to guide the CFAR's growth and evolution over the next 5 years: 1) Provide comprehensive infrastructure support to all intramural HIV/AIDS investigators aimed at expanding the robust program of inter- disciplinary, collaborative HIV research that addresses NIH Research priorities. 2) Continue development of a pipeline of next generation HIV/AIDS investigators through strong support of Early Stage Investigators and engagement of established investigators from outside the field of HIV/AIDS research. 3) Foster critical synergies through Core-Core interactions and engagement of new and existing Strategic Partnerships. 4) Expand the relevance, reach, and impact of HIV/AIDS research by implementing and supporting community engagement and outreach. 5) Further enhance and support collaborative activities throughout the global network of CFARs. Support services will be enhanced by increased institutional support from Duke's School of Medicine and Department of Surgery. Through our Strategic Planning process, we have identified eight priority areas that represent opportunities for further development during the next funding cycle. These include: 1) the `Southern HIV Epidemic'; 2) HIV Co-Morbidities, Co-Infections, and Complications; 3) Latency and Eradication; 4) Health Disparities; 5) Vaccine Design and Evaluation; 6) Mental Health and Substance Abuse; 7) the HIV Organ Policy Equity (HOPE) Act; and 8) Emerging Infections. Finally, to ensure the continued high-quality support for intramural HIV/AIDS investigators, the EC has formulated a Leadership Transition Plan, vetted by the institution, in which Dr. Georgia Tomaras and Dr. Susanna Naggie will become Director and Co-Director, respectively. The CFAR looks forward to developing and exploring these timely opportunities within Duke and across the CFAR network throughout the next funding cycle.