Integrated Small Animal Imaging Research Resource

摘要 对癌症的小动物模型进行成像已经成为癌症研究的重要组成部分。的 综合小动物成像研究资源（iSAIRR）已经证明了其广泛的用途， 应用于推进乳腺、肺、前列腺、卵巢、头颈部、胰腺、结肠直肠 和脑癌不断发展的成像技术也提供了不同的，但互补的， 用于评估潜在生物学和机制、改进诊断和检测的成像方法，以及 监测癌症治疗的效果。为了充分利用这一快速变化的成像领域， 为了提供更广泛的成像能力和服务，iSAlRR现在提供更广泛的 用于小动物体内成像和组织/器官离体成像的成像模式和技术 提高了运营效率和成本效益。iSAIRR现在包括以下内容 子核心：1）磁共振成像和光谱（MRIS）; 2）光学成像（OI）; 3)microPET/SPECT/CT成像，在此周期中增加了图像和数据分析组件;以及 4)成像化学。成像化学服务不需要CCSG资金。成像 化学子核心成立于2015年，使用UCCCC发展基金， 为我们的用户提供强大的功能和专业知识，包括专门设计的造影剂，并与 新的回旋加速器设施和发展放射化学计划，使独特的成像方法。 在本供资期内，iSAIRR进行了战略性调整，以更好地支持正在进行的 未来的研究。新的技术总监和扩大的教师队伍增强了核心领导力 监督委员会代表我们的用户和核心服务不断变化的需求。成像 兽医技术支助分中心被解散，采用了一种更有效的模式。训练 兽医技术人员的工作根据需要分布在所有模式中， 运营商9.4T MRI扫描仪最近进行了升级，并计划扩展microPET/ SPECT/CT成像服务和功能。展望未来，超声成像子核心将 已建立，并提供给用户，具有独立和辅助使用的收费服务结构（没有 CCSG资金要求）。经过内部审查并根据用户的要求，图像分析组件 先前包含在UCCCC图像计算、分析和存储库核心（ICAR）中的 进入ISAIR。更具体地说，它已被纳入microPET/SPECT/CT子核心。等 整合通过提供更多有机和包容性的服务，提高了该子核心的效率， 分子成像

ABSTRACT Imaging small animal models of cancer has become an essential and integral part of cancer research. The Integrated Small Animal Imaging Research Resource (iSAIRR) has demonstrated its broad usage and applications in advancing research in breast, lung, prostate, ovarian, head and neck, pancreatic, colorectal, and brain cancer. Evolving imaging technologies have also made available different, but complementary, imaging methods for assessing underlying biology and mechanisms, improving diagnosis and detection, and monitoring effects of cancer therapies. To take full advantage of this rapidly changing imaging landscape, and to provide a wider spectrum of imaging capabilities and services, the iSAlRR now offers a broader spectrum of imaging modalities and techniques for in vivo imaging of small animals and ex vivo imaging of tissue/organ specimens with improved operational efficiency and cost effectiveness. The iSAIRR now includes the following Subcores: 1) Magnetic Resonance Imaging and Spectroscopy (MRIS); 2) Optical Imaging (OI); 3) microPET/SPECT/CT imaging, with the image and data analysis components added in this cycle; and 4) Imaging Chemistry. CCSG funds are not requested for the Imaging Chemistry services. The Imaging Chemistry Subcore was established in 2015 using UCCCC Developmental Funds, and brings distinctive capabilities and expertise to our users, including specifically designed contrast agents, and collaborates with the new Cyclotron Facility and developing radiochemistry program enabling unique imaging approaches. During the current funding period, the iSAIRR has been strategically restructured to better support ongoing and future research. Core leadership has been enhanced with new technical directors and an expanded Faculty Oversight Committee representing the changing needs of our users and services of the Core. The Imaging Veterinary Technology Support Subcore was dissolved and a more efficient model has been adopted. Trained veterinary technicians’ effort is distributed across all modalities as needed, with an increased contribution from operators. The 9.4T MRI scanner was recently upgraded, and there are plans to expand the microPET/ SPECT/CT imaging services and capabilities. Going forward, an Ultrasound Imaging Subcore will be established, and available to users with a fee-for-service structure for independent as well as assisted use (no CCSG funds requested). After an internal review and following users’ requests, the image analysis component previously included in the UCCCC Image Computing, Analysis, and Repository Core (ICAR), was incorporated into ISAIRR. More specifically, it has been incorporated into the microPET/SPECT/CT Subcore. Such integration has enhanced the efficiency of this Subcore by providing more organic and inclusive services in molecular imaging.