Targeted drug discovery against blood-feeding parasite nematodes of animals

该项目旨在确定更可持续的牲畜线虫寄生虫控制策略，这些寄生虫每年给澳大利亚的羊毛和肉类行业造成超过4亿美元的损失。该项目希望鉴定出新的杀线虫剂，并利用高通量药物发现筛选与尖端的组学方法相结合的方法来产生关于寄生虫生物学的知识，以针对线虫生存的重要关键分子途径，即它们的吸血行为。该项目的预期成果包括可能加强控制这些寄生虫的国际努力以及杀线虫剂的商业化。这将为澳大利亚和世界各地的农业生产者带来重大利益。

This project aims to identify more sustainable control strategies of nematode parasites of livestock, which cost more than 400 million yearly to the Australian wool and meat industry. The project expects to identify novel nematicides and generate knowledge of the parasite biology using a combination of high-throughput drug discovery screens with cutting-edge OMICs approaches to target a key molecular pathway of importance to the survival of nematodes, namely their blood-feeding behaviour. Expected outcomes of this project include a likely enhancement of international efforts in controlling these parasites as well as nematicides commercialisation. This should provide significant benefits to agricultural producers in Australia and worldwide.