Evaluating Chinese-speaking community-dwelling elders in the United States with the Uniform Data Set

项目摘要 痴呆症是65岁或以上成年人的常见疾病。认知测试可以提高对糖尿病的诊断 老年人的痴呆症。老年华裔美国人诊断不准确或延误的风险很高 由于缺乏关于认知测试的标准数据而导致的痴呆症诊断。阿尔茨海默病 美国各地的ADC评估正常衰老、轻度认知障碍(MCI)、阿尔茨海默氏症 疾病(AD)和其他类型的痴呆症在老年人中的应用 统一数据集(NACC UDS)评估。评估包括临床面谈、体检、 认知测试和功能评估。采血进行载脂蛋白Eε4(apoEε4)基因分型 通常作为标准痴呆症评估的一部分完成。来自不同文化和人群的数据 已经有关于UDS认知测试的报道，但很少有针对会说中文的人的报告。这个 国家反兴奋剂机构正在努力收集中国的中国人口的UDS数据。然而，认知数据 中国的中文可能不会推广到在美国的华人人口。鉴于不断增长的美国 中国人口，以及他们日益增长的痴呆症护理需求，至关重要的是制定规范的数据，以 在确定认知缺陷方面提供精确度。拟议的研究旨在生成UDS 使用一组年龄和受教育程度不同的健康老年华裔美国人的认知数据 成就。为了证明认知测试的敏感性，我们将评估认知与 表现与人口统计(例如，年龄、性别和教育)、经验(例如，达到的年龄和年龄)有关 美国)、临床(如认知状况、日常生活能力和行为症状)，以及 遗传变量(例如，载脂蛋白ε4)。参赛者必须认知正常，主要是会说中文，并且 年龄65岁或以上。所有参赛者将接受3小时的面对面NACC UDS评估。中国人 NACC UDS工具的翻译将由中英文双语工作人员在 西奈山伊坎医学院阿尔茨海默病研究中心(ISMMS)。基座 根据我们以前招募老年华裔美国人进行临床研究的经验，我们预计招收150人 正常对照组，为期2年。回归模型将被用来检验认知和认知之间的关系 表现与人口统计、经验、临床和遗传变量有关。ISMMS的ADRC一直在 在美国成功招募和评估会说西班牙语的长辈。这个项目建立在这个基础上 评估老年华裔美国人的经验，这是美国增长最快的少数群体。我们的结果 将支持开发用于检测和诊断认知功能减退的标准化数据 在这一缺乏服务的人群中患上痴呆症。这些数据还将提供有价值的跨国比较和 为NACC数据库增值。

Project Summary Dementia is a common disorder in adults aged 65 or above. Cognitive tests can improve the diagnosis of dementia in older adults. Elderly Chinese Americans have a high risk of inaccurate diagnosis or delayed diagnosis of dementia due to the absence of normative data on cognitive tests. The Alzheimer Disease Centers (ADCs) around the United States assess normal aging, Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD), and other types of dementia in older adults using the National Alzheimer's Coordinating Center's Uniform Data Set (NACC UDS) evaluation. The evaluation consists of a clinical interview, medical exam, cognitive testing, and functional assessment. Blood collection for Apolipoprotein E ε4 (APOE ε4) genotyping is commonly completed as part of the standard dementia evaluation. Data from several cultures and populations have been reported for UDS cognitive tests but few reports in Chinese speaking individuals are available. The NACC is working to collect UDS data for the Chinese population in China. However, cognitive data for Chinese in China might not be generalized to the Chinese population in the US. Given the growing US Chinese population, and their increasing need for dementia care, it is critical to develop normative data to provide precision in the determination of cognitive deficit. The proposed study is designed to generate UDS cognitive data using a cohort of healthy elderly Chinese Americans with a wide range of age and educational attainment. To demonstrate the sensitivity of the cognitive tests, we will assess the relationship of cognitive performance with demographic (e.g., age, gender, and education), experiential (e.g., year and age arrived at the United States), clinical (e.g., cognitive status, activities of daily living, and behavioral symptoms), and genetic variables (e.g., APOE ε4). Participants must be cognitively normal, primarily Chinese speaking, and aged 65 or above. All enrollees will undergo a 3-hour in-person NACC UDS evaluation. The Chinese translation of the NACC UDS instruments will be administered by the bilingual English/Chinese staff at the Alzheimer's Disease Research Center (ADRC) at Icahn School of Medicine at Mount Sinai (ISMMS). Based on our prior recruitment experience of elderly Chinese Americans for clinical study, we expect to enroll 150 normal controls in a 2-year period. Regression models will be used to examine the relationship of cognitive performance with demographic, experiential, clinical, and genetic variables. The ADRC at ISMMS has been successful in recruiting and evaluating Spanish speaking elders in the US. This project builds on this experience to evaluate elderly Chinese Americans, the fastest growing minority group in the US. Our results will support the development of normative data for the detection and diagnosis of cognitive decline and dementia in this underserved population. The data will also provide valuable cross-country comparison and add value to the NACC database.