Developing Cryosuit - usability and performance validation of our portable, rapid cooling device for heat-related illness.

**开发冷冻设备-我们的便携式快速冷却设备针对与热相关的疾病进行可用性和性能验证。**由热带来的疾病和并发症对世界各地的人口健康和经济产生重大影响。如果不迅速进行降低核心体温的治疗，中暑会导致重要器官损伤，导致严重虚弱或死亡。2000-2009年间，中暑等与中暑相关的疾病花费了英国38.5亿GB[CCC.org-2019]。到2030年，热压力将使全球经济每年损失1.8万亿GB的生产力和医疗保健[联合国，2019年]。因此，全球变暖和极端天气模式的日益规律性推动了对治疗HRI的新技术的迫切需求，2018年环境审计委员会的一份报告预测，在没有政府干预的情况下，英国与热相关的死亡人数到2050年将增加两倍。Crygenx旨在通过冷冻管从根本上颠覆GB 3.60亿GB的冷疗中暑治疗市场；我们的便携式快速冷却设备用于现场治疗HRI。它紧凑、自给自足、重量轻，易于操作，在任何情况下都可以有效地部署，克服了目前冷却方法的后勤障碍和资源依赖。关键是，冷冻服将使救生冷却尽可能快地开始；影响患者结局的最大单一因素。在我们最初的冷冻服原型的基础上--初步测试的数据显示，与现有的现场HRI治疗方法相比，该原型的冷却速度快2.5倍，持续时间长3倍，成本降低70%--这个实验性开发项目将优化技术，以展示成为公认的医疗解决方案所需的可用性、安全性和有效性。在伯明翰大学医院NHS基金会信托基金的支持下，我们将通过以人为中心的设计原则将我们的技术开发成全尺寸的V2原型，并在布鲁内尔大学、空气救护车、Balfour Beatty和英国特种部队。项目的输出将是：*符合人体工程学设计的TRL6原型和集成气体输送系统的包装*临床数据集和来自最终用户现场试验的验证

**Developing the Cryosuit - usability and performance validation of our portable, rapid cooling device for heat-related illness.**Illness and complications brought on by heat has a significant impact on population health and economies worldwide. Heatstroke causes vital organ damage, leading to serious debilitation or death, if treatment to lower core body temperature is not administered quickly.Heat-related illnesses(HRI) such as heat stroke cost the UK £3.85bn between 2000-2009 \[CCC.org-2019\]. By 2030, heat stress will cost the global economy £1.8 trillion/year in lost productivity and healthcare\[UN,2019\].Global warming and the increasing regularity of extreme weather patterns is therefore driving an urgent need for new technologies to treat HRI, with a 2018 Environmental Audit Committee report predicting "heat-related deaths are set to treble by 2050" in the UK without Government intervention.Cryogenx aims to radically disrupt the £360m 'cold therapy' heat illness treatment market with Cryosuit; our portable rapid cooling device for treating HRI in-the-field. Compact, self-powered and lightweight, it's easy to operate and can be effectively deployed in any scenario, overcoming the logistical barriers and resource dependency of current cooling methods.Critically, Cryosuit will enable life-saving cooling to be initiated as rapidly as possible; the single largest factor influencing patient outcome.Building on our initial Cryosuit prototype - which data from preliminary tests shows to have 2.5x faster cooling rate, 3x duration, and 70% reduction in cost compared to existing field HRI treatment methods - this experimental development project will optimise the technology to demonstrate the usability, safety and efficacy required to be a recognised healthcare solution.With support form University Hospitals Birmingham NHS Foundation Trust, we'll develop our technology via human-centred-design principles into a full-scale V2 prototype, validated in field-trials with Brunel University, Air Ambulance, Balfour Beatty and UK Special Forces.The projects outputs will be:* Ergonomically designed TRL6 prototype and packaging with integrated gas delivery system* Clinical datasets and validation from end-user field trials