An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-II

项目摘要 纽约结构生物学中心(NYSBC)拥有并运营NYX光束线 位于布鲁克海文的国家同步加速器光源II(NSLS-II) 国家实验室(BNL)，并为国家实验室成员机构的利益而运作 NYSBC和非联盟成员结构生物学家社区。我们在寻找 购买Dectris Eiger2 XE 9M大分子X射线探测器的资金 结晶学。这种先进的、高速的探测器读数将显著 增加样本的吞吐量，从而增加能够 在规定的时间内被起诉。高帧速率将允许我们执行 先进的结晶学方法，这在我们目前的实验中是不可能的 设置，如系列结晶学、超快光栅化和潜在的超越 数据收集过程中的辐射损害。Nyx一直在使用原型像素进行操作 面阵探测器系统公司(HF-4M)的阵列探测器 NSLS-II。虽然来自该探测器的数据质量与其他探测器相当 现有的探测器，ADSC在几年前停止运行，结果是 探测器不再可用，并且开始出现故障。为了保持对 用户们，我们当务之急是用现代像素阵列取代ADSC HF-4M 探测器，预计在接下来的8-10年内仍将有用和可用 好几年了。尤其重要的是，在临时 关闭高级光子源以进行2022年的设施升级 NIH资助的项目对同步加速器接入的需求预计将增加 戏剧性的。2021年有了这个探测器，纽约证券交易所将大大 加强NIH资助的NYSBC财团成员、非 财团成员以及做好充分准备提供不间断的访问 由于APS的暂时关闭，NIH资助的项目。

Project Summary The New York Structural Biology Center (NYSBC) owns and operates the NYX beamline at the National Synchrotron Light Source II (NSLS-II) which is located at the Brookhaven National Laboratory (BNL) and operated for the benefit of the member institutions of the NYSBC and the community of non-consortium-member structural biologists. We seek funds to acquire a Dectris Eiger2 XE 9M X-ray detector for macromolecular crystallography. This advanced, high-speed readout of the detector will significantly increase the throughput of samples and therefore increase the number of projects that can be prosecuted in a set amount of time. The high frame rate will allow us to perform advanced crystallographic methods that are not possible with our current experimental setup, such as serial crystallography, ultra-fast rastering and potentially outrunning radiation damage during data collection. NYX has been operating with a prototype pixel array detector from Area Detector Systems Corporation (HF-4M) since its inception at NSLS-II. While the data quality from this detector has been comparable with other available detectors, ADSC ceased to operate several years ago with the result that the detector is no longer serviceable and is starting to fail. In order to remain valuable to users, it is imperative that we replace the ADSC HF-4M with a modern pixel array detector with the expectation that it will remain useful and serviceable for the next 8-10 years. Of particular importance is performing this upgrade prior to the temporary shutdown of the Advanced Photon Source for a facility upgrade in 2022 when the demand for synchrotron access for NIH-funded projects is expected to increase dramatically. Having this detector in place in 2021 will allow NYX to significantly enhance the NIH-funded research programs of the NYSBC consortium members, non- consortium members as well as be fully prepared to provide uninterrupted access to NIH-funded projects due to the temporary closure of the APS.