Electroanatomical Mapping for Shared Translational Research

项目摘要/摘要 我们请求资金收购圣裘德/雅培EnSite精密电解剖测绘 促进弗吉尼亚州亨特·霍姆斯·麦奎尔当前和新的协作翻译研究的系统 医学中心，以及与弗吉尼亚联邦大学的研究人员合作。这一现状-- ART系统可进行诊断性心脏电生理(EP)和血流动力学研究，密度高 心律失常标测和治疗性消融。虽然它是为心脏和血管研究而设计的，但它可以 用于记录和刺激中枢和周围神经系统的电信号。2它的主要特征 职责是更换和升级对退伍军人管理局资助的核心研究至关重要的过时设备，同时扩大 跨不同专业的研究途径(心脏病学、麻醉学、神经学、药剂学)和 与我们的大学附属机构弗吉尼亚联邦大学合作。 该设备的特殊功能包括记录电信号、测量压力 波形，电刺激目标组织，应用射频消融，执行自动计算机化 心律失常期间复杂电活动的高密度三维标测。由于其 广泛的能力，它可以使不同子专业的研究人员受益。相比之下，目前的制度 (GE Prucka心脏实验室)的诊断能力更有限(记录和刺激，但不消融)， 并有一个过时的手册，顺序映射系统(VS自动)，这使得它不足以 由退伍军人事务部以及NIH和AHA等外部机构资助的当前和未来的研究提案。 VA核心研究项目将研究术后心房颤动(POAF)的新疗法，3 室性早搏致心肌病(PVC-CM)，4-5脱髓鞘和 神经退行性疾病6和旨在改善心脏保护和抗心律失常的治疗 线粒体的功能，即细胞的能量来源，在衰老和与缺血相关的心脏病中。其他7个 具有直接平移应用的研究包括测试不同的消融能量和技术 优化安全有效的消融治疗人类心律失常，8并测试不同麻醉类型的患者 心脏模型，以优化其在患者中的应用。 VCU的合作将利用该设备来确定抗心律失常和心脏保护 以炎性细胞因子及其受体为靶点的新型或重新定位药物的保护机制 抗缺血相关损伤和心力衰竭。9，10

PROJECT SUMMARY / ABSTRACT We request funds to acquire the St Jude/Abbott Ensite Precision Electroanatomical Mapping System to facilitate current and new collaborative translational research at Hunter Holmes McGuire VA Medical Center, and collaborations with investigators at Virginia Commonwealth University. This state-of-the- art system can perform diagnostic cardiac electrophysiologic (EP) and hemodynamic studies, high density arrhythmia mapping and therapeutic ablation. 1 Although designed for cardiac and vascular studies, it can be applied to record and stimulate electrical signals in the central and peripheral nervous systems. 2 Its primary role is to replace and upgrade out-of-date equipment critical to core VA-funded research, while expanding avenues of investigation across different specialties (cardiology, anesthesia, neurology, pharmacy) and collaboration with our university affiliate, Virginia Commonwealth University. The equipment’s specific capabilities include to record electrical signals, measure pressure waveforms, electrically stimulate target tissue, apply radiofrequency ablation, perform automated computerized high density 3-dimentional mapping of complex electrical activations during cardiac arrhythmias. Due to its broad capabilities, it can benefit researchers across different subspecialties. In contrast, the current system (GE Prucka CardioLab) has more limited diagnostic capabilities (recording and stimulation but no ablation), and has an out of date manual, sequential mapping system (vs automated) which makes it inadequate for current and future research proposals funded by VA, and extramural agencies such as NIH and AHA. Core VA research projects will investigate novel therapies for postoperative atrial fibrillation (POAF), 3 premature ventricular contraction-induced cardiomyopathy (PVC-CM), 4 5 demyelinating and neurodegenerative conditions 6 and cardioprotective and antiarrhythmic therapies targeted at improving function of mitochrondria, i.e. the cell’s energy sources, in ageing and ischemia related heart disease. 7 Other studies with direct translational applications include the testing of different ablation energies and techniques to optimize safe and effective ablation in human arrhythmia, 8 and testing different anesthesia types in diseased heart models in order to optimize their application in patients. VCU collaborations will utilize the equipment to determine the anti-arrhythmic and cardioprotective mechanisms of novel or ‘repurposed’ drugs that target inflammatory cytokines and their receptors to protect against ischemia-related injury and heart failure. 9,10