Genotyping for epidemiology studies

癌症基因组研究实验室(CGR)的成立是为了研究基因变异对癌症易感性和结果的贡献。CGR与DCEG内部研究计划中的流行病学家、生物统计学家和基础研究科学家合作，提供了进行全基因组发现研究和有针对性的地区性方法来确定各种形式癌症的可遗传决定因素的能力。在体细胞研究方面已经开始了新的工作，使用肿瘤/正常组织核酸在感兴趣的对象中进行跨平台比较。在CGR内部增加了一个分子和数字病理学研究支持小组，以支持这些努力。CGR在癌症研究从规划到发表的所有阶段为DCEG提供支持，包括实验设计和项目管理、样本处理、基因分型和测序分析设计和执行、组织研究支持、生物信息管道的开发和实施，以及下游研究和分析支持。这些因素使CGR成为NCI驱动的科学努力的独特合作中心。

The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians, and basic research scientists in DCEG’s intramural research program, the CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. New work has begun in somatic research with the use of tumor/normal tissue nucleic acids for cross-platform comparisons in subjects of interest. A support group for molecular and digital pathology research within CGR has been added to support these efforts. CGR supports DCEG in all stages of cancer research from planning to publishing, including experimental design and project management, sample handling, genotyping and sequencing assay design and execution, tissue research support, development and implementation of bioinformatic pipelines, and downstream research and analytical support. These factors make CGR a unique collaborative center for NCI-driven scientific endeavors.