SWG1: HIV/TB Scientific Working Group

项目总结/摘要 普罗维登斯/波士顿（P/B）CFAR的艾滋病毒-结核病科学工作组（SWG）于年成立。 2017年1月，在Brown/Lifespan和BUMC HIV的互补科学专业知识的基础上， 和结核病（TB）研究小组及其国内和国际网站，以了解 艾滋病毒和结核病及其各自的全球流行病的双向影响。目前，对结核病和艾滋病毒/结核病的研究 占P/B CFAR资助研究基础（FR B）的主要组成部分。有独特 P/B CFAR艾滋病毒/结核病工作组在三个领域开展创新研究的机会：第一， 结核病研究纳入艾滋病毒/结核病，解决与艾滋病毒自然史及其 发病机制;第二，将生物成分引入目前主要是临床和/或 行为;第三，吸引初级和高级研究人员到该领域。P/B CFAR承诺采取 通过创建这个艾滋病毒-结核病工作组来利用这些机会。 工作组将把目前从事艾滋病毒/结核病问题的调查人员与目前不从事这方面工作的调查人员聚集在一起。 参与这项研究，分享想法，并确定潜在的子研究，在他们目前资助的项目， 以及潜在的新项目。这将通过每两个月一次的午餐会来完成，布朗和 和BU、CFAR年度结核病会议和SWG执行委员会将每半年举行一次会议， 审查参与这些活动的情况，并评估这些活动是否产生了预期的结果和产出。 此外，SWG将通过应用其专业知识来提高其他P/B CFAR核心的生产率， 实现SWG的具体目标。因此，工作组将通过促进新的 和创新项目以及最大限度地提高CFAR核心的生产力。

Project Summary/Abstract The Providence/Boston (P/B) CFAR's HIV-TB Scientific Working Group (SWG) was established in January 2017, and has built on the complementary scientific expertise of the Brown/Lifespan and BUMC HIV and tuberculosis (TB) research groups, and their domestic and international sites, in order to understand the bidirectional effects of HIV and TB and their respective global epidemics. Currently, research on TB and HIV/TB accounts for a major component of the funded research base (FRB) of the P/B CFAR. There are unique opportunities for the P/B CFAR HIV-TB SWG to develop innovative research in three areas: first, to refocus research on TB to incorporate HIV/TB, addressing issues pertaining to the natural history of HIV and its pathogenesis; second, to introduce biologic components to research that is at this point primarily clinical and/or behavioral; and third, to attract junior and senior researchers to the field. The P/B CFAR has committed to take advantage of these opportunities by creating this HIV-TB SWG. The SWG will bring together investigators currently working on HIV/TB issues with those not currently involved in this research to share ideas and identify potential sub-studies within their currently funded projects, as well as potential new projects. This will be done via bi-monthly lunch meetings, alternating between Brown and BU, annual CFAR sponsored TB meetings, and the SWG Executive Committee will meet semiannually to review participation in these activities and assess whether they are leading to the desired outcomes and outputs. In addition, the SWG will add to the productivity of the other P/B CFAR Cores by applying their expertise to addressing the SWG Specific Aims. Thus, the SWG will add value both by facilitating the development of new and innovative projects as well as by maximizing the productivity of the CFAR Cores.