Vaccines Enabling HIV Prevention Targeting Germinal Center Enhancement with Engineered Slow Release Nanoparticles

基于颗粒的HIV免疫原的共递送作为下一代HIV疫苗：HIV疫苗研究的主要焦点是开发免疫原，其引起靶向包膜蛋白（Env）的广泛中和抗体应答。虽然该领域主要集中于免疫原设计和可溶性抗原，但抗原的靶向和受控递送尚未受到太多关注，并且是HIV领域中需要解决的空白。定制的免疫原（例如Env、单体、天然和/或天然样三聚体、核酸/RNA例如mRNA、自扩增RNA）与用于递送的纳米颗粒上的有效多价抗原展示组合可以提供促进针对HIV的强且长寿命的中和抗体应答并指导针对HIV中和抗体的亲和力成熟的策略。

Particle-Based Co-Delivery of HIV Immunogens as Next-Generation HIV Vaccines: A major focus of HIV vaccine research has been the development of immunogens that elicit broadly neutralizing antibody responses targeting the envelope protein (Env). While the field has predominantly focused on immunogen design and soluble antigens, the targeted and controlled delivery of antigens has not received much attention and is a gap in the HIV field that needs to be addressed. Tailored immunogens (such as Envs, monomers, native and/or native-like trimers, nucleic acids/RNA such as mRNAs, selfamplifying RNAs) combined with an effective multivalent antigenic display on nanoparticles for delivery may provide a strategy to promote strong and long-lived neutralizing antibody responses against HIV and direct affinity maturation toward HIV neutralizing antibodies.