PROPHET

《先知--未来医疗保健的个性化预防路线图》将制定个性化预防战略研究和创新议程(SRIA)，以支持实施创新、可持续和有效的个性化方案，以预防常见的慢性病。生物医学技术的进步(包括组学数据和数字工具)使个体层面的风险分层成为可能。然而，个性化预防方法的发展必须伴随着医疗保健系统的转型，包括公民参与、医疗保健专业教育和解决组织、社会和法律问题。Prophet将围绕三个主要活动方面的利益攸关方参与和SRIA共同创建过程展开：测绘、评估和建设。首先，我们将总结、评估并与相关利益攸关方讨论所有这些新技术可以协同的程度(地图绘制)。其次，我们将设计一个全面的框架(先知框架)，其中将包括评估个性化预防方法及其被公共卫生当局采用的所有必要方面(评估)。第三，我们将支持引入个性化预防计划，为其设计提供指导方针，与医疗专业人员(特别是与政策制定者合作的人员)接触，并在人口层面提高关于个性化预防(建筑)的好处的健康素养。Prophet将与欧盟层面的其他主要当前和即将采取的行动进行联络，例如ICPerMed、欧洲伙伴关系(EP)、CSA Beyond 100万Genome(B1 MG)和EP on Transform Health and Care Systems。该财团由12个欧盟国家的18个受益者和2个附属实体以及来自不同目标群体的大量利益攸关方组成。

"PROPHET - a PeRsOnalized Prevention roadmap for the future HEalThcare" will develop a Strategic Research and Innovation Agenda (SRIA) for Personalized Prevention, in order to support the implementation of innovative, sustainable and effective personalized programmes to prevent common chronic diseases. Technological biomedical advances (including omics data and digital tools) make risk stratification at the individual level possible. However, development of Personalized Prevention approaches must be accompanied by healthcare system transition, including citizen engagement, healthcare professional education and addressing organisational, social and legal issues. PROPHET will be centred around stakeholder engagement and the SRIA co-creation process in relation to three main strands of activities: Mapping, Assessment, and Building. Firstly, we will summarize, evaluate and discuss with the relevant stakeholders the extent to which all these new technologies can synergise (Mapping). Secondly, we will design a holistic framework (the PROPHET Framework) that will include all the necessary aspects to appraise Personalized Prevention approaches and their adoption by Public Health Authorities (Assessment). Thirdly, we will support the introduction of Personalised Prevention Programmes by providing guidelines for their design, engaging with healthcare professionals (especially those working with policy makers), and increasing health literacy at the population level on the benefits of Personalized Prevention (Building). PROPHET will liaise with other key current and forthcoming initiatives at EU level, such as ICPerMed, European Partnership (EP) PerMed, the CSA Beyond 1 Million Genomes (B1MG), and the EP on Transforming Health and Care Systems. The consortium consists of 18 beneficiaries and 2 affiliated entities across 12 EU Countries, and a large number of stakeholders already engaged from different Target Groups.