RADOV (RADiation harvesting of bioactive peptides from egg prOteins and their integration in adVanced functional products)

RADOV从食品辐照消毒和延长保质期的成熟辐射工艺应用，以及几十年来对体内辐射生物效应的基础研究，探索基于辐射诱导片段化从卵蛋白生产生物活性肽的全新途径，以及包含卵蛋白衍生肽的新产品原型。来自电子加速器的高能辐射将用于生产肽，收集有关肽结构，辐射条件和相关生物活性特性的结果将是该项目的重要成果之一。为了扩大电离辐射的应用并展示其广泛的应用范围，将设计和开发含有生物活性蛋白质/肽的新产品，并使用电子束辐照来制造它们。特别是，将开发两种目标产品作为辐射诱导片段化的蛋源性AMP的示范产品：肽类抗菌/抗氧化水凝胶伤口敷料和肽接枝活性食品包装膜。

RADOV moves from the well-established radiation process applications in food irradiation for disinfection and shelf-life increase, and from several decades of fundamental studies of the biological effects of radiation in vivo, to explore completely new routes for the production of bioactive peptides from egg proteins based on radiation-induced fragmentation, and new product prototypes that incorporate egg protein-derived peptides. High energy radiation from electron accelerators will be used to produce peptides and the collection of the results acquired regarding the peptide structure, irradiation conditions, and related bioactivity properties will be one vital output of the project. To expand the application of ionizing radiation and to demonstrate the broad scope of its applications, new products containing bioactive proteins/ peptides will be designed and developed with the use of electron beam irradiation to manufacture them. In particular, two target products will be developed as demonstrators of egg-derived AMPs by radiation-induced fragmentation: peptideladen antimicrobial/antioxidant hydrogel wound dressings and peptide-grafted active food packaging film.