Discovery of antiviral inhibitors of Ebola virus replication

埃博拉病毒（EBOV）会导致人类严重疾病，死亡率高达90%。 迫切需要具有针对EBOV的有效和选择性活性的新疗法来预防和治疗EBOV。 埃博拉病毒病（EVD）的治疗。我们建议执行一个创新的高通量筛选 使用独特的反向遗传学系统。这一筛选有望产生新的抑制剂， EBOV复制，将作为药物化学击中领先的努力的起点。如果成功，我们 将提供一个或多个针对EBOV感染的新电极导线系列。

Ebola viruses (EBOV) cause severe illnesses in humans with a high rate of mortality that approaches 90%. Novel therapies with potent and selective activity against EBOV are urgently needed for the prevention and treatment of Ebola virus disease (EVD). We propose to execute an innovative high throughput screening campaign using a unique reverse genetics system. This screen is expected to yield new inhibitors targeting EBOV replication that will serve as starting points for medicinal chemistry hit-to-lead efforts. If successful, we will deliver one or more new lead series targeting EBOV infection.