2021 Tissue Repair and Regeneration GRC & GRS

项目摘要 能够促进组织修复和再生的治疗方法将对人类和动物产生巨大的影响 健康由于损伤后组织修复和再生受损导致的医疗保健成本是全球范围内的一个重大问题。 预计到2023年将达到数百亿美元[1]。医疗保健系统面临着 越来越多的慢性伤口无法愈合，这在老年人和糖尿病患者中很常见， 以及其他形式的受损愈合，如创伤性损伤后的瘢痕形成和纤维化。瘢痕和纤维化 可以影响所有器官系统，包括皮肤，心脏，肺，肝脏和肾脏，并且是常见的年轻人，否则 健康的个体。这些类型的病理性，失调的修复反应在体内影响数百万人， 并证明迫切需要新的治疗和疗法来促进组织修复 和再生。因此，我们必须了解分子和细胞机制， 控制体内的修复和再生，并揭示为什么有些生物体可以再生， 其他人不能。这是将再生医学发展到一个新水平的关键。再生能源研究进展 医学通过创新研究而发生，也通过这一突破的快速传播 通过促进科学界的交流与合作，在这一领域开展工作。戈登研究 组织修复和再生会议（GRC-TRR）在提供一个 论坛交流了过去三十年的最新发现和创新。 本次会议的主要目标是汇集顶级学术研究人员与临床医生， 职业科学家和高级PI，以激发和促进新的想法，并产生新的合作 这将推动再生医学的新发现和新疗法。具体来说，我们计划了九个 科学会议，从涉及模型生物见解的基础科学和数学 模型化，向更实用和临床的方面发展，如组织工程、炎症在组织中的作用等 破坏和愈合，以及临床治疗的最新方法。这将带来新的见解， 我们如何精确地操作发育缺陷或损伤患者的组织和器官， 一个再生的结果。每隔一年召开的2021年GRC-TRR将是本组织的第15次会议。 成功的系列会议。过去所有会议的计划都可以在GRC网站上找到。

Project Summary Therapies that can promote tissue repair and regeneration will have immense impact on human and animal health. Healthcare costs due to impaired tissue repair and regeneration following injury are a significant global burden, and are projected to be in the tens of billions by 2023 [1]. The healthcare system is faced with ever increasing numbers of non-healing chronic wounds, common in the elderly and in people with diabetes, as well as other forms of impaired healing, such as scarring and fibrosis following traumatic injury. Scarring and fibrosis can affect all organ systems including the skin, heart, lungs, liver and kidneys, and is common young, otherwise healthy individuals. These types of pathological, dysregulated repair responses in the body affect millions of people each year and demonstrate the critical need for new treatments and therapies to facilitate tissue repair and regeneration. Therefore it is imperative that we understand the molecular and cellular mechanisms that control repair and regeneration in vivo, and uncover the reasons why some organisms can regenerate while others cannot. This is key in progressing regenerative medicine to a new level. Advances in regenerative medicine occur through innovative research, and also through the rapid dissemination of breakthroughs in this field through fostering communication and collaboration in the scientific community. The Gordon Research Conference on Tissue Repair and Regeneration (GRC-TRR) has played an absolutely critical role in providing a forum for communicating the latest discoveries and innovations for the past three decades. The main objective of this conference is to bring together the top academic researchers with clinicians, early career scientists and senior PIs, in order to spark and facilitate new ideas and to generate new collaborations that will drive new discoveries and novel therapies in regenerative medicine. Specifically, we have planned nine scientific sessions, ranging from basic science involving insights from model organisms and mathematical modelling, to the more applied and clinical aspects, such as tissue engineering, the role of inflammation in tissue destruction and healing, as well as the latest approaches in clinical treatments. This will bring novel insights into how we can precisely manipulate tissues and organs in patients with developmental defects or injuries to provide a regenerative outcome. The 2021 GRC-TRR, which convenes every other year, will be the 15th meeting of this successful conference series. Programs for all of the past meetings can be found at the GRC website.