Pharmaceutical Sciences and Pharmacogenomics

项目总结 药学和药物基因组学(PSPG)研究生课程是一个独特的，动态的， 加州大学旧金山分校当代药学和药物基因组学专业 旧金山吸引了不同的教职员工和学生，他们对将基础科学应用于 在药物开发和精确药物治疗方面具有挑战性的研究课题。研究生课程反映了 基因组学、定量和系统药理学、治疗学领域令人振奋的科学发展 以及对药学和药理学具有深远影响的计算。这个 PSPG研究生计划的目标是教育和培训博士生概念化、设计和执行 现代药学所涵盖的跨学科科学领域的创新科学研究 科学。该项目汇集了17个系的66名资金充足的教职员工。这 多学科和独特的研究生课程有双重重点：1)药学和药物 发展，包括分子和系统药理学、药物输送和治疗性生物工程， 基因治疗和药代动力学/药效学和建模；以及2)药物基因组学， 遗传学和基因组学在开发新疗法和优化药物使用方面的应用 针对个别患者的精准医疗。培训计划包括一系列核心课程，提供 深入了解药学和药物基因组学的原理，包括 创新系统药理学新核心课程。核心课程由选修课补充，包括 先进的药物传递和药代动力学原理，遗传学和细胞生物学原理，生物信息学， 组织和器官生物学、CRISPR治疗学和计算机编程。学生们还参加了 实验室轮换，使他们接触到可用于论文研究的各种潜在项目 以及一门关于负责任的研究行为的大学课程。该计划使学员沉浸在文化中 通过一个期刊俱乐部，由四个基础科学研究生项目的学生组成，重点是 关于研究生物学的定量方法，这是一个研讨会项目，吸引了领先的学术、监管机构 以及工业科学家、学生研究报告和年度务虚会。该计划的目标是招聘8- 每年12名优秀博士生，外加至少一名药学博士/博士结合学位的学生。 代表人数不足的少数族裔学生通过一些教职活动积极招募，并代表 我们20%的学生。毕业后，新的PSPG博士科学家将拥有伦理、知识和工具 成为独立的研究人员所必需的，也是产生影响的激情和热情 在制药科学和药物基因组学领域的整个职业生涯的贡献。

PROJECT SUMMARY The Pharmaceutical Sciences and Pharmacogenomics (PSPG) Graduate Program is a unique, dynamic, contemporary program in pharmaceutical sciences and pharmacogenomics at the University of California San Francisco that attracts diverse faculty and students who share a common interest in applying basic sciences to challenging research topics in drug development and precision drug therapy. The graduate program reflects exciting scientific developments in the area of genomics, quantitative and systems pharmacology, therapeutics and computation that have far-reaching implications to the pharmaceutical and pharmacological sciences. The goal of the PSPG graduate program is to educate and train Ph.D. students to conceptualize, design and execute innovative scientific research in the interdisciplinary scientific areas encompassed by modern pharmaceutical sciences. The program brings together 66 well-funded faculty members spanning 17 departments. This multidisciplinary and unique graduate program has a dual focus: 1) pharmaceutical sciences and drug development, including molecular and systems pharmacology, drug delivery and therapeutic bioengineering, gene therapy and pharmacokinetics/pharmacodynamics and modeling; and 2) pharmacogenomics, the application of genetics and genomics for the development of novel therapeutics and the optimal use of drugs in individual patients for precision medicine. The training program includes a series of core courses providing an in-depth understanding of the principles of pharmaceutical sciences and pharmacogenomics, including an innovative new core course in systems pharmacology. Core courses are complemented by electives covering advanced drug delivery and pharmacokinetic principles, principles of genetics and cell biology, bioinformatics, tissue and organ biology, CRISPR therapeutics and computer programming. Students also participate in laboratory rotations that expose them to the diversity of potential projects available for their dissertation research and a university-wide course on responsible conduct of research. The program immerses trainees in the culture of science through a journal club with students across four basic science graduate programs that are focused on quantitative approaches to studying biology, a seminar program which brings in leading academic, regulatory and industrial scientists, student research presentations, and an annual retreat. The program goal is to recruit 8- 12 outstanding Ph.D. students per year, plus at least one student for a combined Pharm.D./Ph.D. degree. Underrepresented minority students are actively recruited through a number of faculty activities and represent 20% of our students. Upon graduation, the new PSPG Ph.D. scientist will have the ethics, knowledge and tools necessary to become independent researchers, and also the passion and enthusiasm to make impactful contributions to the pharmaceutical sciences and pharmacogenomics field throughout their career.