DEVELOPMENT OF A SMARTPHONE-BASED INFRARED-FLUORESCENCEIMAGING INTRAORAL DEVICE (SMART-IR-ID) FOR DENTIST-GUIDED REALTIME SELF-MONITORING OF PERIODONTAL DISEASE

项目概要： 牙周病（PD）是一种常见的感染性/炎症性疾病， 然而，PD的高患病率（47%的美国成年人 牙周炎）使其成为公共卫生问题，具有高达4420亿美元的社会经济负担 每年. PD通常由牙科医生、牙医或牙周病医生跟踪牙槽骨来诊断 高度和牙龈高度通过口内X光片（X射线）和牙周探测。牙科X光检查 最可靠的口内成像工具，用于识别牙齿/牙洞状况和骨病变;然而， X光不能发现早期牙周病变，也不能显示牙周袋（PP）的形貌。还有， 牙科X光不能作为常规筛查工具，在随访期间检查PD的进展 这是因为它的电离辐射造成健康风险和问题。因此，周期探测是 完整PD诊断和随访检查的标准方法。牙周组织的结构状态 软组织可以通过牙周袋深度测量、牙龈出血和牙龈出血的视觉迹象来估计。 炎症（红肿）。据我们所知，仍然没有可靠的技术可以 提供PD进展期间PP和发炎牙龈的3D结构信息。的目的 建议是开发一种基于智能手机的红外荧光成像口内设备（Smart-IR-ID）， 测量PP和牙龈炎症的3D结构，用于牙科医生引导的自我检查和PD跟踪。 我们建议通过两个具体目标来解决这个问题：1）研究红外（IR）荧光 成像方法，以开发红外口腔内设备，可以精确地提供和释放所需的最低限度 2）研制双模块光学传感器 和基于智能手机的3D建模系统，用于数字3D IR成像和报告 PP和牙龈炎症。我们提出的项目是创新的，作为一个基于智能手机的口内IR 荧光成像系统在显示PP和牙周组织感染软组织的3D结构方面是一种有效的方法， 完全未被探索的研究领域。这项工作的预期成果是提供开创性的 我们的精密医疗口腔成像设备的原型集成到mHealth平台。聪明- 特别是IR-ID，为下一阶段结合成像和治疗能力提供了可能性。 我们的项目意义重大，因为这项研究将开发一个特定于平台的模型， 其他口腔内诊断和治疗设备，将PD管理从现场临床护理转变为 从诊所设施到牙医指导的自我护理。

PROJECT SUMMARY: Periodontal disease (PD), a common infectious/inflammatory disease, is preventable for much of the population by early detection and treatment; however, the high prevalence of PD (47% of Americans adults having periodontitis) makes it a public health concern, having a socio-economic burden of up to $442 billion each year. PD is typically diagnosed by the dental hygienist, dentist, or periodontist tracking alveolar bone height and gingival height through intraoral radiographs (X-rays) and periodontal probing. Dental X-rays are the most reliable intraoral imaging tool for identifying tooth/cavity conditions and bone lesions; however, dental X-rays cannot detect early periodontal lesions and visualize the topography of periodontal pocket (PP). Also, dental X-rays cannot be used as a routine screening tool to exam the progression of PD during the follow-up period because its ionizing radiation poses health risks and concerns. Periodontal probing is, therefore, the standard approach for complete PD diagnosis and follow-up checkups. The structural status of the periodontal soft tissues can be estimated by pocket depth measurement, gingival bleeding, and visual signs of gingival inflammation (redness and swelling). To the best of our knowledge, there is still no reliable technology that can provide 3D structure information of the PP and inflamed gingiva during PD progression. The objective of this proposal is to develop a smartphone-based infrared-fluorescence-imaging intraoral device (Smart-IR-ID) to measure the 3D structure of the PP and gingival inflammation for dentist-guided self-exam and tracking of PD. We propose to address this objective through 2 specific aims: 1) To investigate the infrared (IR) fluorescence imaging approach to develop IR intraoral devices that can precisely deliver and release the minimal required dosage of imaging agents into inflamed gingiva and PP; and 2) To develop the dual-module optical sensors and smartphone-based 3D modeling system for digital 3D IR-imaging and reporting the 3D measurements of PP and gingival inflammation. Our proposed project is innovative as a smartphone-based intraoral IR fluorescence imaging system in visualizing the 3D structure of PP and infected soft tissue of periodontium is a completely underexplored research area. The expected outcome of this work is to provide the pioneering prototype for our precision medicine-based intraoral imaging device integrated into a mHealth platform. Smart- IR-ID, in particular, opens the possibility of combining imaging and therapeutic capabilities at the next stage. Our project is significant because this research will develop a platform-specific model that can be linked to other intraoral diagnostic and therapeutic devices, transforming PD management from on-site clinical care in clinic facilities to dentist-guided self-care at the point-of-need.