CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)

该合同建议开发、优化和测试使用脐带血造血干细胞生产HIS小鼠，包括新生儿胸腺组织的联合移植。适应性和先天人类免疫系统的综合表征将包括测试其对标准人类疫苗接种和同种异体移植的反应能力。优化和改进所选择的模型集中在增加先天淋巴样细胞的数量，促进淋巴组织的发育，从而导致人类免疫系统更健壮和完整的发育。

This contract proposes to develop, optimize, and test the production of HIS mice using hematopoietic stem cells from cord blood, including the co-transplantation of neonatal thymic tissue. Comprehensive characterizations of the adaptive and innate human immune systems will include testing its ability to respond to a standard human vaccination and an allograft. The chosen models for optimization and improvement center on increasing populations of innate lymphoid cells which facilitate lymphoid tissue development, that in turn would lead to more robust and complete development of the human immune system.