THE GENETICS AND MULTI-OMICS SPECIMENS CORE (GMSC)

GMSC摘要 世界各地的老龄化人口，特别是发达国家的老龄化人口，面临着日益沉重的 神经退行性疾病。基因研究极大地促进了我们对这些复合体的理解。 疾病。现在很明显，遗传学以外的研究，如转录组学、蛋白质组学或表观基因组学 需要充分了解神经退行性变和健康衰老的生物学，识别新的生物标志物和 确定新的目标。基因组学和多组学样本核心(GMSC)的目标是获得、保存和 质量控制(QC)来自AABC参与者的生物样品(DNA、RNA和血浆)。核心将会产生 其他AABC项目将使用的所有参与者的GWAS、APOE和多基因风险评分。我们会 还产生纵向多组体(经典血液分析、抗苗勒氏激素(AMH)、阿尔茨海默病 (AD)生物标志物和神经炎症蛋白质组学)血液数据将用于项目1-4以确定 AD、变构负荷、炎症、生活方式行为和绝经过渡的生物标志物阳性 对这些项目都起到了重要作用。

ABSTRACT FOR GMSC Aging populations worldwide, particularly in developed countries, face an increasing burden of neurodegenerative diseases. Genetic studies have greatly contributed to our understanding of these complex diseases. Now it is clear that studies beyond genetics, such as transcriptomics, proteomics, or epigenomics are needed to fully understand the biology of neurodegeneration and healthy aging, to identify novel biomarkers and identify novel targets. The goal of the Genomics and Multi-omics Specimens core (GMSC) is to obtain, bank and quality control (QC) biospecimens (DNA, RNA and plasma) from AABC participants. The core will generate GWAS, APOE and polygenic risk scores for all participants that will be used by other AABC Projects. We will also generate longitudinal multi-omic (classic blood analytes, anti-Müllerian hormone (AMH), Alzheimer disease (AD) biomarkers, and neuroinflammation proteomics) blood data that will be used for Projects 1-4 to determine biomarker positivity for AD, allosteric load, inflammation, lifestyle behaviors, and the menopausal transition that are instrumental for those projects.