Speaker-Listener Coupling and Brain Dynamics During Naturalistic Verbal Communication in Alzheimer's Disease

项目摘要 阿尔茨海默病（Alzheimer's disease，AD）是一种进行性的严重衰弱性疾病， 和记忆功能，并与日常功能的残疾和死亡风险增加有关。 语言功能是AD的一个重要损害领域。AD患者表现出广泛的语言 被认为会导致受影响个人社会孤立的困难，对生活质量产生负面影响 以及患者、护理人员和家庭成员的福祉。我们的行政补充的主要目标 是推进我们对语言理解缺陷背后的大脑机制的理解， AD患者为了实现这一目标，我们将利用功能磁共振成像任务范式和神经认知模型， 最近，作为母项目的一部分，与斯坦福大学合作， 阿尔茨海默病研究中心（ADRC）。我们现在建议扩展我们的原有目标， 旨在通过检查言语的预期和整合成分来建立这些发现 处理，重点是默认模式网络的异常组织，在早期AD患者。 至关重要的是，为了实现这一目标，我们将应用由美国国家科学院开发的新颖的实验和分析方法。 斯坦福大学的母项目，以收集AD数据作为拟议补充和资源的一部分， 斯坦福大学ADRC（P30 AG 066515）临床核心和成像核心。具体来说，我们将研究（1） 自然言语交际中说话人-听话人脑耦合及其与叙事的关系 AD和年龄匹配的健康对照者的理解和功能性沟通能力;以及（2） 自然主义言语交际背后的时间整合窗口的完整性及其与 AD患者和年龄匹配的健康对照者的叙事理解和功能性沟通能力。我们 研究将提供有关沟通障碍神经生物学起源的关键信息 AD将为旨在改善痴呆症语言和社会功能的治疗和策略提供信息。

Project Abstract Alzheimer’s disease (AD) is a progressive and severely debilitating disease that negatively affects cognitive and memory function and is linked to increased disability in everyday functioning and risk of mortality. Language function is a crucial area of impairment for AD. Individuals with AD show a wide range of language difficulties which are thought to lead to social isolation in affected individuals, negatively affecting quality of life and well-being for patients, caregivers, and family members. The major goal of our Administrative Supplement is to advance our understanding of the brain mechanisms underlying speech comprehension deficits in patients with AD. To accomplish this goal, we will leverage fMRI task paradigms and neurocognitive models we have recently developed as part of the parent project and ongoing work in collaboration with the Stanford Alzheimer’s Disease Research Center (ADRC). We now propose to extend our original aims with two new Aims designed to build on these findings by examining anticipatory and integrative components of speech processing, with a focus on aberrant organization of the default mode network, in patients with early AD. Critically, to achieve this goal, we will apply the novel experimental and analytic approaches developed by the parent project at Stanford to AD data collected as part of the proposed supplement and resources provided by the Stanford ADRC (P30AG066515) Clinical Core and Imaging Core. Specifically, we will investigate (1) speaker-listener brain coupling during natural speech communication and its relation to narrative comprehension and functional communication abilities in AD and age-matched healthy controls; and (2) the integrity of temporal integration windows underlying naturalistic verbal communication and its relation to narrative comprehension and functional communication abilities in AD and age-matched healthy controls. Our studies will provide critical information regarding the neurobiological origins of communication impairments in AD and will inform therapies and strategies aimed at improving language and social function in dementia.