Novel actions of neurosteroids on GABA (A) receptor trafficking

项目摘要 本申请是R01 NS108378的多样性补充，标题为 神经类固醇与GABAAR贩运“的PI是保罗·戴维斯博士和斯蒂芬·莫斯博士 在塔夫茨大学。多样性候选人是诺埃尔，他是哈佛大学实验室的一名博士前初学者。 莫斯医生。诺埃尔有资格成为多元化候选人，这是因为瓜达尼亚人的分类和作为一个 第一代大学毕业生在美国农村地区关岛长大。这份副刊是 为诺埃尔在实验室的头几年提供资金，让她：1)接受指导和培训，以便在 追求科学事业，2)致力于初步实验，提交NRSA F31 团契。斯蒂芬·莫斯博士培养了20名研究生，其中许多人是独立的 作为一名调查人员，他在指导方面有很好的记录。诺埃尔的项目直接 与父母拨款的目的有关，该目的的核心是神经类固醇在调节 GABA膜转运的磷酸依赖性调节。为了做到这一点，她将学习 并应用电生理学和生物化学技术。总体而言，这个项目将为Noell带来 广泛接触“前沿”神经科学研究中使用的当代方法 让她为独立调查员的职业生涯做好准备。其他导师关系互动 诺埃尔和莫斯博士之间的合作由补充资金提供，包括建立演示技能，写作 赠款和科学出版物，设计实验的能力，通过 特邀演讲者，以及与制药行业合作者的互动。这笔资金将 重要的是，为诺埃尔提供丰富的机会，这样她就可以与 更广泛的神经科学界。多样性副刊将为诺埃尔通往 在科学上有积极的未来，继续在塔夫特大学建立多样性。中的活动 成为可能的导师和丰富将是诺埃尔作为一个 独立调查员。

Project Summary This application is for a diversity supplement to the R01 NS108378, entitled “Novel actions of neurosteroids on GABAAR trafficking” the PIs of which are Dr. Paul Davies and Dr. Stephen Moss at Tufts University. The diversity candidate is Noell, a beginning pre-doctoral student in the lab of Dr. Moss. Noell qualifies as a diversity candidate due to Guamanian classification and being a first-generation college graduate having grown up in Guam, a U.S. rural area. This supplement is to fund Noell’s first years in the lab for her to: 1) receive mentorship and training to advance in pursuit of a career in science, 2) work on preliminary experiments to submit a NRSA F31 fellowship. Dr. Stephen Moss has trained 20 graduate students, many whom are independent investigators, and has a well-respected track record of mentorship. Noell’s project is directly related to aims of the parent grant, which centers on the role that neurosteriods play in mediating the phospho-dependent regulation of GABAAR membrane trafficking. To do this, she will learn and apply techniques in electrophysiology and biochemistry. Overall, this project will give Noell broad exposure to contemporary methodologies used in “cutting edge” neuroscience research and prepare her for a career as an independent investigator. Other mentorship interactions between Noell and Dr. Moss funded by the supplement include building presentation skills, writing grants and scientific publications, ability to design experiments, exposure to the field through invited speakers, and interactions with pharmaceutical industry collaborators. The funding will importantly provide Noell with enrichment opportunities so she can connect with others in the broader neuroscience community. The diversity supplement will bridge Noell’s path towards a positive future in science and continue to build diversity at Tuft’s University. The activities in mentorship and enrichment made possible will be critical in Noell’s development as an independent investigator.