Training Africans to Lead and Execute Neurological Trials & Studies (TALENTS)

项目摘要/摘要 非洲面临着日益沉重的非传染性疾病负担，成为发病率增长最快的原因 和死亡率，其中许多是神经系统疾病。临床研究是治疗的基础进展 允许科学家测试药物、疗法或策略的有效性和安全性的医学；以及临床 神经科学研究很有希望帮助减少神经系统疾病的死亡人数。然而，这些研究 这导致了因果/风险因素的发现&药物/干预措施很少来自非洲人口， 在神经系统疾病中首当其冲。随着利用量身定做的干预措施的精准医学的兴起， 在产生循证治疗方面缺乏种族-民族多样性可能是一个挑战，如果非洲人 祖先将真正受益于这些有针对性的治疗。支持有限的研究人员池的一种方法是 非洲进行神经学研究和试验是为了让选定的个人接受协调一致的教育， 培训、指导和网络机会，从而提高他们成为临床成功的几率 研究人员，从而在非洲大陆创造了一支为整个领域做出学术贡献的干部队伍 神经系统疾病，包括非洲的地方性疾病。培训非洲人领导的目标是 并执行神经学试验和研究(人才)计划，旨在建立可持续的神经学研究 通过美国和非洲组织之间的伙伴关系提高非洲的能力。六名学者将被录取 每年都参加这个项目，并参加教育、指导和网络活动。人才特定目标 是：1)从跨国人才库中挑选和留住24名有前途的多学科学者)致力于事业 在神经学研究方面；2)增加学者的科学知识、专业技能、动力和 神经学研究证书(证书课程、临床研究硕士学位、智库 会议和科学会议活动)；3)加强以下方面的指导效益和联网机会 学者(一致的一对一辅导方法和在线网络活动)；4)在赠款结束时 尼日利亚伊巴丹大学设立神经学独立硕士学位的时期， 有多名教员是新近受训的人才；5)评估 程序。我们预计，人才将建立一个可持续的个人网络，拥有以下方面的专业知识 神经学研究准备在非洲承担领导和学术教师的角色，并能够指导 该地区历代受过良好培训并取得成功的神经学研究人员。

PROJECT SUMMARY / ABSTRACT Africa faces a growing burden of non-communicable diseases as the fastest growing cause of morbidity and mortality, many of which are neurological disorders. Clinical studies are the foundation advancements in medicine allowing scientists to test the efficacy and safety of a drug, therapy or strategy; and clinical neuroscience research holds great promise to help mitigate the toll of neurological disease. However, the studies that lead to discovery of causal /risk factors & drugs/interventions rarely emanate from African populations, which bear a major brunt of neurological diseases. With the rise of precision medicine utilizing tailored interventions, lack of race-ethnic diversity in generating evidence-based treatments can be a challenge if people of African ancestry are to truly benefit from these targeted therapies. One way to bolster the limited pool of researchers in Africa conducting neurological research and trials is to expose select individuals to coordinated education, training, mentoring, & networking opportunities, thereby raising their odds of becoming successful clinical researchers, thus creating a cadre of people on the continent making academic contributions to the overall field of neurological diseases, including those conditions endemic to Africa. The goal of the Training Africans to Lead and Execute Neurological Trials & Studies (TALENTS) program, is to build sustainable neurological research capacity in Africa through partnerships between US and African organizations. Six scholars will be accepted into the program each year and exposed to educational, mentoring, & networking activities. TALENTS Specific Aims are: 1) To select & retain 24 promising multidisciplinary scholars from a cross-national pool) committed to careers in neurological research; 2) To increase scholars' scientific knowledge, professional skills, motivation, & credentials, in neurological research (Certificate Program, Master’s degree in Clinical Research, Think Tank Sessions, and Scientific Conference events); 3) To enhance mentoring benefits and networking opportunities for Scholars (congruent one-on-one mentoring approach and online networking activities); 4) By end of the grant period to create an independent Master’s degree in Neurological Research at the University of Ibadan in Nigeria, with several member of the faculty being recent TALENTS trainees; 5) To evaluate the effectiveness of the Program. We anticipate that TALENTS will establish a sustainable network of individuals with expertise in neurological research poised to assume leadership and academic faculty roles in Africa, and able to mentor successive generations of locally well-trained and successful neurological researchers in the region.