A Hydrogel Ionic Circuit-Based Electrical Stimulation System for Restoration of Denervated Muscles After Peripheral Nerve Injuries

项目摘要：肌肉电刺激(ESTM)是一种很有前途的失神经康复方法 周围神经损伤后的肌肉。目前的肌肉肌萎缩侧索硬化症的治疗效果有限 他们所应用的低Estim强度。将高强度的Estm应用于肌肉是一个巨大的挑战。 这是因为所有的电流器件都能传导电子电流。需要电化学反应才能转化为 电子电流到设备-组织界面上的离子电流。这些反应会引发化学反应。 当刺激强度较高时，会损害组织的变化和温度升高。因此，有一个 迫切需要新一代肌肉刺激器，能够安全地应用高强度肌注治疗有效 保护失去神经的人体肌肉。 长期目标是开发有效的基于Estim的治疗方法，以保护失去神经支配的人体肌肉 周围神经损伤。这项提议的总体目标是开发一种新型的ESTM设备，它可以 安全地应用高强度的ESTM，以改善失神经肌肉的保存。在具体目标1中，我们将 确定安全应用高强度ESTM的最佳ESTM装置设计。我们的工作假说 无线耦合、离子电流传导的水凝胶离子回路(HIC)设备不会引发任何 电化学反应，所以它可以最大限度地减少不良影响，当应用高强度的ESTM。具体而言 目的2，我们将确定我们的装置所应用的高强度ESTM的保存效果 使用临床前大鼠周围神经损伤模型失神经肌肉。我们的工作假设是高- 与目前常用的低强度运动相比，强度运动可以提高肌肉的保存性。 学习。将对感觉恢复、运动恢复和肌肉质量进行评估。 这个项目的基本原理是，开发一种无线耦合的、完全基于离子电流的 刺激器将显著增加在不造成组织损伤的情况下使用的强度。这 将改善周围神经损伤后的肌肉康复结果，这是 电流刺激器。我们的成果将建立一个最佳的设备设计，以实现安全、高效和高效的 强度评估应用。我们还将展示高强度ESTM方案的体内疗效 肌肉保护。我们的高影响力项目将为进一步的开发和测试提供强有力的理由 我们用于治疗周围神经损伤后失神经肌肉的设备。这最终将导致 以改善周围神经损伤患者的康复效果和生活质量。

Project Summary: Muscle electrical stimulation (EStim) is a promising rehabilitation modality for denervated muscles after peripheral nerve injuries. Current muscle EStim devices have limited therapeutic efficacy due to the low EStim intensity they apply. Applying high-intensity EStim to muscles presents a significant challenge. This is because all current devices conduct electron currents. Electrochemical reactions are required to convert the electron currents to the ion currents at the device-tissue interface. These reactions can induce chemical changes and temperature increase that can damage tissues when the EStim intensity is high. Thus, there is a critical need for a new generation of muscle stimulators that can safely apply high-intensity EStim for efficacious preservation of denervated human muscles. The long-term goal is to develop efficacious EStim-based therapy to preserve denervated human muscles after peripheral nerve injuries. The overall objectives of this proposal is to develop a novel EStim device that can safely apply high-intensity EStim to improve the preservation of denervated muscles. In Specific Aim 1, we will determine the optimal EStim device design for safe application of high-intensity EStim. Our working hypothesis is that a wirelessly coupled, ion current-conducting hydrogel ionic circuit (HIC) device does not induce any electrochemical reactions, so it can minimize adverse effects when applying high-intensity EStim. In Specific Aim 2, we will determine the efficacy of high-intensity EStim applied by our device for the preservation of denervated muscles using a pre-clinical rat peripheral nerve injury model. Our working hypothesis is that high- intensity EStim can improve muscle preservation compared to the low-intensity EStim typically used in current studies. The sensory recovery, motor recovery and muscle quality will be evaluated. The rationale for this project is that the development of a wirelessly coupled, completely ion current-based stimulator will significantly increase the EStim intensity that can be applied without causing tissue damage. This will lead to improved muscle rehabilitation outcomes following peripheral nerve injury that is not possible with current stimulators. Our outcome will establish an optimal device design to enable safe and efficient high- intensity EStim application. We will also demonstrate the in vivo efficacy of high-intensity EStim protocol for muscle preservation. Our high impact project will provide a strong justification for further development and testing of our device for treating denervated human muscles following peripheral nerve injuries. This will ultimately lead to better rehabilitation outcomes and improved quality of life for patients suffering from peripheral nerve injury.