Development of optoelectronically active nerve adhesive for accelerating peripheral nerve repair
Development of optoelectronically active nerve adhesive for accelerating peripheral nerve repair
批准号:
10811395
负责人:
Bin Duan
金额:
$43.73万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-09-22 至 2025-08-31
关键词:
AccelerationAdhesionsAdhesivesAffectAirAllergic ReactionAminesAutologous TransplantationAxonBasic ScienceBehaviorBiocompatible MaterialsBreathingCatecholsCell ProliferationCell SizeCellsCicatrixConsumptionCovalent InteractionDefectDenervationDevelopmentDevicesDiseaseDistalDopamineDrynessElectric StimulationElectricityEnvironmentExtracellular MatrixFibrin Tissue AdhesiveForeign-Body ReactionGenesGoalsHealth Care CostsHeartHyaluronic AcidHydrogelsIn VitroInflammatoryInjuryIsothiocyanatesLifeLightMicrosurgeryModelingMotorMuscleMuscular AtrophyNatural regenerationNerveNeuritesNeuronsOperative Surgical ProceduresOutputPatientsPerformancePeripheralPeripheral NervesPeripheral nerve injuryPhysiologicalProceduresProcessProliferatingPropertyPublic HealthQuality of lifeQuinonesRationalizationRattusRecoveryRiskSchwann CellsSensorySiliconSkeletal MuscleSpinal GangliaSulfhydryl CompoundsSurgical suturesSwellingSystemTemperatureTestingThickThioureaTimeTissue AdhesivesTissuesWorkaxon growthbiomaterial compatibilitycell behaviorchronic painclinical applicationcohesioncytotoxicitydesigndisabilityfabricationfunctional disabilityhealingimplantationimprovedin vitro activityin vivoinjury and repairinnovationlight intensitymechanical propertiesmetermotor function recoverymotor impairmentnerve damagenerve gapnerve injurynext generationnoveloperationperipheral nerve regenerationperipheral nerve repairperipheral nerve transectionprotein expressionregeneration functionrepairedresponsesciatic nervesocialsubmicrontissue injurytissue regenerationtransmission processwireless
中文摘要
项目总结
英文摘要
Project Summary
Peripheral nerve (PN) injury represents a major public health problem that leads to functional impairment and
permanent disability. Microsurgical suturing, standard approach for long-gap PN repair, is a time-consuming
procedure and causes nerve damage, inflammatory foreign body reactions, and scar formation, which delay
the PN regeneration. As potential alternatives, tissue adhesives have been developed to reduce operation time
and avoid secondary damages. However, current commercially available tissue adhesives, like fibrin glue and
others, are far from ideal, considering cytotoxicity, tissue compression due to extensive swelling, and poor
mechanical properties. We have developed a novel dual network nerve adhesive (NA) consisting of catechol
modified hyaluronic acid and decellularized peripheral nerve matrix hydrogels. Our NAs illustrated significantly
higher adhesion strength and adhesion force, compared to catechol modified HA only and commercial fibrin
glue. The NAs supported Schwann cell proliferation and improved PN repair after transection injury comparing
to fibrin glue. However, both sensory and motor functions were still incompletely recovered after microsuturing
or NA repair in the transected and long-gap nerve injury models. In this proposal, we will further incorporate
innovative optoelectronic biomaterials (i.e., Si based μ-solar cells) within the NA to develop next generation of
optoelectronically active NAs (optoENAs) for long-gap PN injury regeneration. The Si based μ-solar cells are in
micrometer size, biocompatible, biodegradable, and photo-stimulable to generate sufficient electrical output.
The specific aims of the studies are (1) to develop functional optoENA and determine how the size and
concentration of μ-solar cells affect NA properties and PN related cell behaviors; and (2) to determine whether
and how optoENAs expedite surgical procedures, facilitate autograft implantation, and promote long-gap PN
repair in a rat model. This proposal will develop a novel and clinically applicable tissue adhesive with enhanced
adhesive performance and optoelectronic properties for improving healing and regeneration of long-gap PN
injury.
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