Pediatric Preclinical Testing Consortium: Coordinating Center-Additional PPTC funding extension

项目摘要 儿科临床前测试联盟(PPTC)的主要目标是开发能够 转化为人类临床实践，有效地优先治疗儿科疾病 癌症。一个有效的协调中心(CC)对联盟的目标至关重要，因为它提供了 广泛的组织、科学和分析专业知识，以支持NCI科学家和PPTC研究 程序。CC还将负责制定、实施和评估 全面的PPTC研究计划，在数据收集和持续计划方面提供领导 评估以确保研究方案朝着PPTC任务取得最佳进展。 提供必要的组织和行政领导，使财团能够 有效运作也将是CC的一项关键职能。RTI作为PPTC拟议CC的目标将 将优化联盟在生成可靠数据方面的进展，以加快开发更多 通过实现以下具体目标，有效治疗癌症儿童： 1.指导联合会成员与儿科肿瘤学社区之间的互动。提供 通过有效的方式运营高效和多产的财团所需的后勤支持 电话会议、网络研讨会、联盟会议和网站。使用这些工具来促进 PPTC成员、制药公司和儿科肿瘤学倡导之间的互动 组织，以确保有希望的新疗法得到有效利用。 2.生成可靠的预测数据，可用于确定儿科治疗药物的优先顺序 癌症。为数据收集和数据统计分析提供高效和可靠的程序 收集自研究项目。 3.为财团提供全面而灵活的科学、统计和分析集合 开发创新研究计划以创建功能联盟所需的资源 儿科临床前测试。开发工具，通过以下方式跟踪每个潜在候选药物的状态 临床前的过程。将联合端数据字典中的变量作为一个要构建的元素进行文档记录 红帽的数据管理系统。

Project Summary The main goal of the Pediatric Preclinical Testing Consortium (PPTC) is to develop models that will translate to human clinical practice and effectively prioritize therapies for the treatment of pediatric cancers. An effective Coordinating Center (CC) will be critical to the Consortium’s goals by providing broad organizational, scientific, and analytic expertise to support NCI scientists and the PPTC Research Programs. The CC will also be responsible for developing, implementing, and evaluating a comprehensive PPTC research program, providing leadership in data collection and ongoing program evaluation to ensure that the research program is making optimal progress toward the PPTC mission. Providing the organizational and administrative leadership necessary to enable the Consortium to function efficiently will also be a key function of the CC. RTI’s goal as the proposed CC for the PPTC will be to optimize Consortium progress in generating reliable data to accelerate the development of more effective treatments for children with cancer by achieving the following specific aims: 1. Guide interactions between Consortium members and the pediatric oncology community. Provide the logistical support necessary to run an efficient and productive Consortium through effective teleconferences, webinars, Consortium meetings, and website. Employ these tools to facilitate interactions between PPTC members, pharmaceutical companies, and pediatric oncology advocacy organizations to ensure that promising new therapies are utilized efficiently. 2. Generate reliable predictive data that can be used for prioritization of therapeutic agents in pediatric cancer. Provide efficient and robust procedures for data collection, and statistical analysis of data collected from the Research Programs. 3. Provide the Consortium with a comprehensive, yet flexible set of scientific, statistical, and analytic resources needed to develop an innovative research program for creating a functional Consortium for pediatric preclinical testing. Develop tools to track the status of each potential drug candidate through the preclinical process. Document variables in a Consortium-side data dictionary as one element to build the data management system in REDCap.