Core A: Administrative and Data Sharing Core

项目摘要：管理核心A 行政核心的目标是多方面的。首先，管理核心A将充当 没有围墙的U54 FTD中心的中央组织小组。管理核心将监督和指导 FTD CWW的所有科学活动并通过设立 加州大学旧金山分校和华盛顿大学球队之间的每月会议。第二，核心意志 为调查人员提供行政、财务和组织方面的支持。它将生成报告 关注中心活动，跟踪里程碑和可交付成果。管理核心还将作为一个 该中心的内部数据共享和管理中心。这样，它既发展了新的，又 利用现有的数据组织合作伙伴关系。最后，管理核心将生成和维护 面向公众的网络资源和数据库，包括Tau代谢途径数据库(TMDB) 和Tau多基因风险评分(Tprs)。行政核心将由高爱梅博士领导 与联合主演詹妮弗·横山博士。如果该中心获奖，核心将招聘一名科学人员 咨询委员会(SAB)，将就该小组的科学和管理方面提供建议。这个 SAB将每年召开会议，就科学方向向CWW提供建议。核心将与美国国立卫生研究院合作 和SAB监督里程碑和交付成果的实现。最终，这一核心将是 直接对CWW的生产力、方向和成功负责。

PROJECT SUMMARY: Admin Core A The objectives of the Administration Core are multi-fold. First, the Admin Core A will serve as the central organizing group for the U54 FTD Center without Walls. The Admin Core will oversee and direct all scientific activities of the FTD CWOW and promote collaboration and communication by setting up monthly meetings between the UCSF and Washington University teams. Secondly, the Core will provide administrative, financial and organizational support for the investigators. It will produce reports on Center activities and keep track of milestones and deliverable. The Admin Core will also serve as an internal data sharing and management hub for the Center. In this way, it both develop new and leverage existing partnerships for data organization. Finally, the Admin Core will generate and maintain public facing web resources and databases, including the Tau Metabolism Pathway Database (TMDB) and the Tau Polygenic Risk Score (TPRS). The Administrative Core will be headed by Dr. Aimee Kao with Co-Lead Dr. Jennifer Yokoyama. If the Center is awarded, the Core will recruit a Scientific Advisory Board (SAB), that will advise on the scientific and management aspects of the group. The SAB will convene annually to advise the CWOW on scientific direction. The Core will work with the NIH and SAB to supervise the achievement of milestones and deliverables. Ultimately, this Core will be directly responsible for the CWOW’s productivity, direction and success.