California National Primate Research Center

项目摘要 这份申请来自位于加州大学的加州国家灵长类研究中心(CNPRC) (加州大学戴维斯分校)寻求通过行政部门获得3,100,000美元的联邦资金 补充改造和改造(A&R)和扩大饲养，为COVID提供恒河猴- 19研究。改造和翻新资金将用于翻新一个半英亩的室外遮阳结构 畜栏，对内部畜栏结构进行维修，翻新并为五个室外围栏提供暖气。这个 中国石油天然气集团公司繁殖群体的扩张将从第一年开始，并在第二年继续。之前的两年 翻新后的室外饲养场将在每个畜栏内安置约70只恒河猴 第一年.翻新并安装暖气的五个户外围栏将在第一年用于畜牧生产 2.这些户外围栏较小，可容纳大约10-15只动物。中国石油天然气集团公司将收购40只年轻恒河猴 加勒比灵长类动物研究中心(CPRC)的猕猴。这些动物将完成CNPRC 90天的隔离，然后将被安置在较小的户外围栏中进行重复测试，以确认它们的病毒状态 然后将它们与来自中国大陆殖民地的幼年恒河猴结合。我们还将使用10个室内群笼作为住房 幼年恒河猴，形成稳定的社会群体，重复病毒筛查，并最终转移到繁殖畜群 未来。在第一年翻新的畜栏将被用来安置另外70只动物，形成第三个畜栏 为扩大种群而饲养的畜栏。从中国人民政治协商会议获得的40只幼年恒河猴将整合到第三只 在户外的围栏里繁殖畜栏和较小的繁殖群。要求在第二年提供资金，以支付PER Diem用于扩大的繁育组，以及雇用额外的工作人员来提供动物护理，群体管理， 和兽医护理需求。需要这笔资金来增加工作人员，因为到第二年，我们将指定大约 350只动物，其中包括来自中国人民解放军的40只动物，用于繁殖和整体种群扩张。他们的初选 任务将分配给扩大的繁殖群体。当200只雌性开始繁殖时，估计的产量 (77%的活出生率/女性)每年将为COVID和大流行增加154只恒河猴 研究。 拟议项目的具体目标是： ·翻新1/5英亩的畜栏和5个户外围栏，用于扩大中国人民解放军的繁育群体 ·建立另外三个繁殖畜栏、五个室外围栏和十个室内帮养笼子，以扩大规模 新冠肺炎育种与未来大流行研究 ·扩大CNPRC动物护理、群体管理、行为和兽医工作人员，以提供护理 对于扩大的殖民地 ·将350只成年恒河猴投入扩大繁殖群体，目标是增加电流 中国石油天然气集团公司年产154名婴儿

PROJECT ABSTRACT This application from the California National Primate Research Center (CNPRC) located on the University of California (UC) Davis campus, seeks to obtain federal funding in the amount of $3,100,000 through the Administrative Supplements for Alteration and Renovation (A&R) and expansion of breeding to provide rhesus macaques for COVID- 19 research. The Alteration and Renovation funds will be used to renovate a shade structure for a single ½ acre outdoor corral, perform repairs to the interior corral structure, and renovate and provide heating to five outdoor pens. The breeding colony expansion for the CNPRC breeding colony will begin in Year 1 and continue in Year 2. Two previously renovated outdoor breeding corrals will be populated with approximately seventy rhesus macaques in each corral in Year 1. The five outdoor pens that are renovated and have heating installed will be used for animal production in Year 2. These outdoor pens are smaller and house approximately 10-15 animals. The CNPRC will acquire forty young rhesus macaques from the Caribbean Primate Research Center (CPRC) in Year 1. These animals will complete the CNPRC 90 day quarantine and will then be housed in the smaller outdoor pens for repeated testing to confirm their viral status before combining them with juvenile rhesus from the CNPRC colony. We will also use ten indoor gang cages for housing of young rhesus, formation of stable social groups, repeat viral screening, and eventual transfer to breeding corrals in the future. The corral that is renovated in Year 1 will then be used to house an additional 70 animals to form the third breeding corral for colony expansion. The forty young rhesus acquired from the CPRC will be integrated into the third breeding corral along with smaller breeding groups in the outdoor pens. Funds are requested in Year 2 to pay the per diem for the expanded breeding group as well as hire additional staff to provide for the animal care, colony management, and veterinary care needs. This funding for additional staff is needed because by Year 2 we will designate approximately 350 animals including the forty animals from the CPRC for breeding and overall colony expansion. Their primary assignment will be to the expanded breeding colony. When the 200 females begin breeding, the estimated production (77% live birth rate/female) will produce an additional 154 rhesus on an annual basis for COVID and pandemic focused research. The specific aims of the proposed project are to: • Renovate one ½ acre corral and five outdoor pens to be used for expansion of the CNPRC breeding colony • Establish three additional breeding corrals, five outdoor pens, and ten indoor gang cages for expanded breeding for COVID-19 and future pandemic research • Expand CNPRC animal care, colony management, behavior and veterinary staff to provide care for the expanded colony • Commit 350 adult rhesus to an expanded breeding colony with the goal of increasing current CNPRC production by 154 infants/year