Training Program for Applied Research and Development in Genomic Medicine

摘要 医疗保健专业人员、科学家和公众正在拥抱医疗保健领域的潜在进步 这是可能的，在某些情况下，通过使用基因组的方法，现在正在交付 和其他个人信息，以改善护理。要确保这些期望成为现实，需要 高素质的临床医生干部--科学家、科学家和临床医生通力合作 推进基因组医学的发现和实施。我们建议一个新的博士后 基因组医学培训计划--《中国应用研究与开发计划》 基因组医学或范例“。该培训计划面向医学博士、药学专业人员和其他临床专家 在博士水平上，博士学位是基于四个前提的：基因组医学：1.将主要由 受过医生培训的临床医生和团队方法是必不可少的。2.需要临床转化型科学家 具有翻译科学方面的核心能力，以及基因组医学方面的专业知识。3. 将需要领导者，这个项目将促进领导力和专业精神的发展。4.遗嘱 通过学术界、医疗保健、私营部门、政府部门的科学领袖改善生活 监管科学和政策，以及其他部门。为了培训个人来满足这些需求， 范型将为最多4名博士后学者提供多年、综合、多学科的 计划，为他们在基因组医学领域的职业生涯做准备。大体上讲，该计划由四个部分组成 主要内容：1)必修课和选修课的授课部分；2)受指导者 研究部分，涉及在已完成项目的指导下确定的研究项目 基因组医学科学家和临床医生；3)临床基因组医学组件，集成 他们进入基因组医学临床实践环境；4)职业发展 构成部分，包括通过在国家会议上发言、参加赠款等方式进行体验式培训 和预算审查，辅导学生和其他活动。培训经验的马赛克 这四个部分将根据以往的经验、教育需求进行量身定做 和学员的研究兴趣，但将集中在UF的三个专业核心： 药物基因组学、癌症基因组学和疾病易感性遗传学/基因组学。我们将依靠 36位才华横溢、协作能力强的多学科导师来执行该项目。范型将 进行持续的评估和质量改进，以确保学员的长期成功。 计划完成后，每个受训人员将被期望拥有以下知识和技能 使他们能够应对证据生成和基因组医学临床应用方面的挑战。

Abstract Healthcare professionals, scientists, and the public are embracing the potential advances in healthcare that are possible, and in some cases being delivered now, through approaches that employ genomic and other personal information to improve care. To ensure these expectations become reality requires a highly qualified cadre of clinician-scientists, scientists and clinicians working collaboratively to advance discoveries and implementation in genomic medicine. We propose a new post-doctoral genomic medicine training program called “Program for Applied Research and Development in Genomic Medicine or PARADIGM”. This training program for MDs, PharmDs, other clinical specialists at the doctoral level, and PhDs is based on four premises: Genomic medicine: 1. will be led primarily by doctorally-trained clinicians and a team approach is essential. 2. needs clinical translational scientists in with core competencies in translational science, and specialized knowledge in genomic medicine. 3. will require leaders, and this program will foster development of leadership and professionalism. 4. will improve lives through scientific leaders in academia, healthcare, the private sector, governmental regulatory science and policy, among other sectors. To train individuals to meet these needs, PARADIGM will provide up to 4 post-doctoral scholars a multi-year, integrated, multidisciplinary program to prepare them for a career in genomic medicine. Broadly, the program is comprised of four major components: 1) a Didactic component of required and optional coursework; 2) a Mentored Research component involving a defined research project under the mentorship of an accomplished genomic medicine scientist and clinician; 3) a Clinical Genomic Medicine component that integrates them into the genomic medicine clinical practice setting; and 4) a Professional Development component including experiential training through presenting at national meetings, participating in grant and budget reviews, mentoring students and other activities. The mosaic of training experiences across these four components will be tailored according to the previous experiences, educational needs and research interests of the trainee, but will be concentrated in three cores of expertise at UF: pharmacogenomics, cancer genomics, and disease susceptibility genetics/genomics. We will rely on 36 highly talented, collaborative, multidisciplinary mentors to execute the program. PARADIGM will undergo continuous evaluation and quality improvement to ensure long-term success of the trainees. Upon program completion, each trainee will be expected to possess knowledge and skills that will enable them to manage the challenges of evidence generation and clinical use of genomic medicine.