Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites

项目摘要 我们泛冠状病毒提案的第一个项目名为“开发针对多种疾病的广泛纳米疫苗”。 冠状病毒受体结合位点。我们团队的专业知识将在结构引导的冠状病毒 纳米颗粒疫苗扩大CoV疫苗保护。该提案利用我们的新平台， 开发有效的、以RBS为焦点的纳米颗粒疫苗，以诱导跨CoV谱系的广泛保护， 逃逸突变和潜在的大流行性冠状病毒。项目的目标是：（1）创建一个 逃避冠状病毒免疫的突变体库（2）开发RBS聚焦的纳米颗粒疫苗， 使用核酸递送针对保守位点的广泛中和抗体和（3）开发疫苗方案 以在不同的CoV中诱导广泛的免疫和保护。

Project Summary The first project of our pan-CoV proposal is titled ‘Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites’. Our team’s expertise will culminate in structurally guided coronavirus nanoparticle vaccines to broaden CoV vaccine protection. This proposal utilizes our novel platform to develop potent, RBS-focused nanoparticle vaccines to induce broad protection across CoV lineages, escape mutations and potential pandemic CoVs that are of concern. The project aims are: (1) Create a library of mutants that escape coronavirus immunity (2) Develop RBS-focused nanoparticle vaccines to induce broadly neutralizing antibodies to conserved sites using nucleic acid delivery and (3) Develop vaccine regimens to induce broad immunity and protection across diverse CoVs.