Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies

摘要 弗吉尼亚大学的癌症研究培训计划（CRTP）汇集了教师和 对癌症生物学有共同兴趣的学员参加癌症研究的综合计划， 教育和发现。CRTP的总体目标是赋予下一代癌症 研究人员与工具，成为未来的领导者，在寻求了解肿瘤学过程， 改善患者预后。我们通过强化的癌症研究培训以及 学术和专业发展活动。总之，这些为受训者提供了（1）一个基础广泛的 癌症生物学基本原理的知识;（2）定义和解决重要研究的能力 在不断变化的环境中使用最新的方法和技术， 生物医学研究;（3）与基础科学家，翻译研究人员，临床 试验者、临床医生和癌症患者/幸存者，以促进发现和改善结果。此续订 应用程序包含了一个新的领导结构，这是由安德鲁达德利博士作为一个 多PI团队，现任PI，Amy Bouton博士。我们请求支持8名博士前学员，他们将 参加纵向培训，包括实验室研究，正式课程工作， 活动，接触癌症的临床/转化方面，专业/职业规划 发展和社区外展机会。42 CRTP教师导师提供了一个强大的，全面的 通过该计划提供这种培训的综合平台。最重要的是，CRTP 由NCI指定的UVA癌症中心提供的强大的癌症研究社区的优势。这 为学员提供了一个机会，使他们能够将自己在基础癌症研究方面的经验应用于以下需要： 改善癌症的诊断和治疗。CRTP在其近几年的发展中取得了很大的成功， 44-年历史。随着我们进入下一个资助期，我们挑战自己，以满足不断变化的 通过不断的评估和项目的发展，癌症研究的前景。在这方面我们 纳入了一些旨在加强社区建设的新举措， 提供应用学习和专业发展的机会，并促进学员与 癌症患者/幸存者。此续订应用程序还包括重要的新增强功能， 严格性和可重复性的培训，导师培训，以及建立咨询委员会， 多元化和包容性。CRTP活动的全部阵列，加上一个专门的教师，有才华的干部， 学员，和充满活力的癌症研究社区，都有助于生产CRTP校友谁是好- 定位成为终身学习者和未来的领导者在不断发展的癌症研究领域。

ABSTRACT The Cancer Research Training Program (CRTP) at the University of Virginia brings together faculty and trainees with a common interest in cancer biology to participate in an integrated program of cancer research, education, and discovery. The overall objective of the CRTP is to empower the next generation of cancer researchers with the tools to become future leaders in the quest to understand oncological processes and improve patient outcomes. We accomplish these goals through intensive cancer research training coupled with academic and professional development activities. Together, these provide the trainees with (1) a broad-based knowledge of fundamental principles in cancer biology; (2) the ability to define and solve vital research questions using the most current approaches and techniques in the constantly changing landscape of biomedical research; and (3) the skills to partner with basic scientists, translational researchers, clinical trialists, clinicians, and cancer patients/survivors to promote discovery and improved outcomes. This renewal application incorporates a new leadership structure prompted by the addition of Dr. Andrew Dudley as part of a multi-PI team with the current PI, Dr. Amy Bouton. We request support for 8 predoctoral trainees who will participate in longitudinal training that includes laboratory research, formal course work, programmatic activities, exposure to clinical/translational aspects of cancer, programming in professional/career development, and community outreach opportunities. The 42 CRTP faculty mentors provide a robust and fully integrated platform through which the program delivers this training. Most importantly, the CRTP takes advantage of the robust cancer research community provided by the NCI-designated UVA Cancer Center. This affords the trainees an opportunity to apply their own experiences in basic cancer research to the need for improved diagnosis and treatments in cancer care. The CRTP has experienced much success over its almost 44-year history. As we move into the next funding period, we challenge ourselves to meet the changing landscape of cancer research through constant assessment and evolution of the program. In this regard, we have incorporated a number of new initiatives designed to reinforce community-building, provide new opportunities for applied learning and professional development, and promote dialogues between trainees and cancer patients/survivors. This renewal application also includes important new enhancements focused on training in rigor and reproducibility, mentor training, and the establishment of an Advisory Committee for Diversity & Inclusion. The full array of CRTP activities, together with a dedicated faculty, talented cadre of trainees, and vibrant cancer research community, all contribute to producing CRTP alumni who are well- positioned to become lifelong learners and future leaders in the continually evolving field of cancer research.