Training in Cardiovascular Research

项目摘要 心血管疾病是美国人死亡的主要原因。持续需要 为医生和博士研究人员提供多学科培训，他们将投入大量的精力， 他们的专业活动的组成部分，以了解病理生理学和治疗 心血管疾病这是犹他州大学（UofU）心血管的第7次更新申请 研究培训计划。自1984年成立以来，该方案已培训了113人， 大部分人都在从事研究事业。在上一个培训期间（2016-2020年）， 支持了21名博士后研究生（5名MD/DO，16名博士），他们都仍然活跃在学术界 机构职能体系我们的学员撰写了218篇出版物，平均2篇第一作者出版物 每个.他们还获得了几项赠款和职业发展奖（如NIH、美国心脏 协会、NSF、ACS）。该计划将继续建立在我们在心血管领域的独特优势之上 在UofU的研究，跨越一系列模型系统的基础和机械研究， 人类的翻译研究。这一培训计划统一了三大心血管研究 UofU健康科学中心的中心：诺拉埃克尔斯哈里森心血管研究和 培训研究所（CVRTI）、医学院心血管医学部和 埃克尔斯人类遗传学研究所的分子医学项目（U2 M2）。这个培训项目 跨越13个UofU部门，包括54个资金充足的教师导师谁领导令人兴奋和富有成效的 心血管研究项目。每个受训者将参加为期两年的培训计划，其中包括 一个研究项目与多学科指导委员会，教学课程，和专业 发展机遇。在此更新申请中，我们继续请求支持以准备8 博士后培训人员将成为心血管研究的领导者。培训计划的下一阶段将 利用扩大的导师库，并实施由两名心脏病医生组成的双重领导结构- 科学家（MPI：Stavros Drakos，MD，PhD和Robin Shaw，MD，PhD），他们的兴趣范围从基本的 生物化学到临床试验。这种更新发生在UofU正在增加其已经相当大的时间 投资于心血管研究培训。CVRTI的600万美元扩建工程正在建设中， 增加心血管研究实验室的数量，研究所已经完全致力于 心血管研究和训练。此外，还有一个校园范围内的心血管战略计划， 该计划旨在加强心血管研究和护理以及UofU。未来五年的训练 该计划将利用UofU的这些新资源和机会，代表一个新的时代， 跨学科合作心血管研究。

PROJECT ABSTRACT Cardiovascular disease is the leading cause of death in the United States. There is an ongoing need to provide multidisciplinary training for physician and PhD investigators who will devote a significant component of their professional activity to understanding the pathophysiology and treatment of cardiovascular disease. This is the 7th renewal application for the University of Utah (UofU) Cardiovascular Research Training Program. Since its inception in 1984, this program has trained 113 individuals who have largely gone on to pursue research careers. During the last training period (2016-2020), this training grant supported 21 post-doctoral research trainees (5 MD/DOs, 16 PhDs) who all remain active at academic institutions. Our trainees have authored 218 publications, with an average of 2 first-author publications each. They have also received several grants and career development awards (e.g. NIH, American Heart Association, NSF, ACS). This program continues to build on our unique strengths in cardiovascular research at the UofU, spanning basic and mechanistic investigation across a range of model systems and translational studies in humans. This training program unifies the three major cardiovascular research centers at the UofU Health Sciences Center: The Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), the Division of Cardiovascular Medicine at the School of Medicine, and the Molecular Medicine Program (U2M2) at the Eccles Institute of Human Genetics. This training program spans 13 UofU departments and includes 54 well-funded faculty mentors who lead exciting and productive cardiovascular research programs. Each trainee will participate in a two-year training program that includes a research project with a multidisciplinary mentoring committee, didactic coursework, and professional development opportunities. With this renewal application, we continue to request support to prepare 8 postdoctoral trainees to be leaders in cardiovascular research. The next stage of the training program will utilize an expanded mentor pool and implement a dual-leadership structure by two cardiology physician- scientists (MPIs: Stavros Drakos, MD, PhD, and Robin Shaw, MD, PhD) whose interests span from basic biochemistry to clinical trials. This renewal occurs at a time with the UofU is increasing its already sizeable investment into cardiovascular research training. A $6M addition to the CVRTI is being constructed to increase the number of cardiovascular research laboratories in an institute already fully dedicated to cardiovascular research and training. Also there is a campus-wide Cardiovascular Strategic Plan being implemented to enhance cardiovascular research and care and the UofU. The next five years of the training program will leverage these new resources and opportunities at the UofU and represents a new era of interdisciplinary collaborative cardiovascular research at our institution.