Laboratory-based Approaches to Understanding the Impact of Low Nicotine Content Cigarette Marketing on Young Adults

项目总结 K07重新提交的总体目标是为Melissa Mercincavage博士提供技能和知识 为了实现她建立独立研究生涯的长期目标，评估小说的影响 烟草产品营销， 重点关注年轻人。该提案使用低尼古丁含量(LNC)香烟 作为典型的新型烟草产品，获得相关专业知识，然后可以应用于其他产品 在未来的研究中。 梅林卡瓦奇博士的培训为她在健康行为研究方面奠定了坚实的基础 方法论与烟草监管科学 专门针对尼古丁的减少。然而，她缺乏正规的培训 在健康传播理论、市场研究和临床试验方法学方面。此外，她的经历 在监管科学的其他方面，以及成人以外的人口，每天吸烟者是有限的。 这个 拟议的研究和培训活动，由安德鲁·斯特拉瑟博士(导师)约瑟夫博士指导 Cappella(共同导师)和一个烟草控制专家委员会将解决这些差距，并使Dr。 梅林卡夫将过渡到一个独特的、独立的职业生涯。拟议的培训计划建立了几个 促进这一转变的目标包括：1)获得健康传播理论知识和 市场研究方法 ，2)扩大烟草监管科学知识，以年轻人为重点 成人烟草使用，以及FDA的一般规定，以及适用于其他烟草产品的规定，以及3)获得 临床试验方法学方面的深入培训。 这些目标将通过以下方式相结合来实现 正式的课程作业、研讨会和讲习班，以及指导指导活动。拟议的研究 包括两项基于实验室的研究，旨在全面解决潜在的LNC的影响 香烟营销(即包装和广告)。第一项研究将考察LNC香烟的影响 包装颜色对吸烟行为、风险认知和危害暴露的影响。 青壮年 吸烟者(n=100) 将完成为期35天、2 x 4的混合析因设计方案，处理尼古丁含量(受试者之间： 非常低与中等)和包装颜色(在主题内：自有品牌与白色、紫色与黑色)。第二 研究将检查LNC香烟广告内容对信息回忆、观看模式和风险的影响 感知。 年轻人(N=340人；吸烟者170人，非吸烟者170人) 将完成一次实验课程 使用2 x 2的受试者间设计来操纵广告准确性(对与错)和健康声明 格式(隐式与显式)。这项提案合乎逻辑地扩展了Mercincavage博士之前的工作，并解决了FDA 烟草产品中心和NCI烟草控制研究分部优先了解 烟草产品营销。此外，这项研究将为两个不同的、重要的潜在监管行动提供信息 -尼古丁减少和营销-减少烟草引起的疾病的公共卫生负担 ，和遗嘱 最终在R01提交的报告中进行随机对照试验，评估特定药物的疗效 营销操纵(通过拟议的研究确定)减少年轻人吸烟的使用。

PROJECT SUMMARY The overall aim of this K07 resubmission is to provide Dr. Melissa Mercincavage with the skills and knowledge to achieve her long-term goal of establishing an independent research career evaluating the impact of novel tobacco product marketing, focusing on young adults. This proposal uses low nicotine content (LNC) cigarettes as an archetypal novel tobacco product to acquire relevant expertise that then can be applied to other products in future research. Dr. Mercincavage's training has given her a solid foundation in health behavior research methodology and tobacco regulatory science specific to nicotine reduction. However, she lacks formal training in health communication theory, marketing research, and clinical trial methodologies. Further, her experience with other aspects of regulatory science, and populations other than adult, daily smokers is limited. The proposed research and training activities, under the guidance of Dr. Andrew Strasser (Mentor), Dr. Joseph Cappella (Co-Mentor), and a committee of tobacco control experts, will address these gaps and enable Dr. Mercincavage to transition to a distinct, independent career. The proposed training plan establishes several objectives to facilitate this transition, including: 1) acquiring knowledge of health communication theory and marketing research methodologies , 2) expanding tobacco regulatory science knowledge to focus on young adult tobacco use, and FDA regulation in general, and as applied to other tobacco products, and 3) obtaining in-depth training in clinical trial methodology. These objectives will be achieved through a combination of formal coursework, seminars and workshops, and directed mentoring activities. The proposed research includes two laboratory-based studies designed to comprehensively address the effects of potential LNC cigarette marketing (i.e., packaging and advertising). The first study will examine the effects of LNC cigarette packaging color on smoking behaviors, risk perceptions, and harm exposure. Young adult smokers (n = 100) will complete a 35-day, 2 x 4 mixed factorial design protocol manipulating nicotine content (between subject: very low vs. intermediate) and pack color (within-subject: own brand vs. white vs. purple vs. black). The second study will examine LNC cigarette advertising content effects on message recall, viewing patterns, and risk perceptions. Young adults (N = 340; 170 smokers, 170 non-smokers) will complete a single laboratory session using a 2 x 2 between-subject design to manipulate advertisement accuracy (true vs. false) and health claim format (implicit vs. explicit). This proposal logically extends Dr. Mercincavage's prior work, and addresses FDA Center for Tobacco Products and NCI Tobacco Control Research Branch priorities to understand effects of tobacco product marketing. Further, this research will inform two distinct, important potential regulatory actions – nicotine reduction and marketing – to reduce the public health burden of tobacco-caused disease , and will culminate in a R01 submission to conduct a randomized controlled trial evaluating the efficacy of specific marketing manipulations (identified through the proposed research) in reducing young adult cigarette use.