COMPREHENSIVE CANCER CENTER CORE SUPPORT GRANT

项目概要/摘要 UAB CCC是亚拉巴马、密西西比、路易斯安那和阿肯色州等州唯一一家NCI指定的综合性癌症中心，这些州癌症死亡率较高，少数族裔人口较多，主要是非洲裔美国人。癌症中心是在其第44年的NCI资助，并继续其转化疗法和癌症差异研究的主要贡献，重点是培训少数民族研究人员。 UAB CCC有242名成员，来自9所UAB学校的30个部门，南方研究所和哈德逊阿尔法生物技术研究所。这些成员每年得到92 055 777美元的直接校外资助。UAB CCC分为六个研究项目，基础，转化和预防和控制各两个-炎症，免疫学和免疫治疗学;癌细胞生物学;实验治疗学;神经肿瘤学;癌症化学预防;和癌症控制与人口科学。2011年至2015年间，成员发表了1，684篇以癌症为重点的同行评审出版物，其中24%是项目内的，16%是项目间的，53%是机构间的。这些成员由11个共享设施提供支持-生物统计学和生物信息学，综合基因组学，高分辨率成像，人体成像，质谱/2D蛋白质组学，微生物组学/Gnotobiotic，临床前成像，招募和保留，结构生物学，组织采购和转基因动物以及正在开发的药物计量学共享设施。我们已经建立了一个I期临床试验计划，开设了一个先进的成像设施，通过亚拉巴马药物发现联盟先进的目标，创建了UAB卫生系统癌症社区网络，现在是一个联盟与哈德逊阿尔法生物技术研究所。除了这些成就之外，我们还建立了癌症结果和生存研究所，并建立了能量平衡和癌症研究人员的临界质量。我们还扩大了我们的少数民族培训计划，自2005年以来，已培训了59名学者，导致306篇出版物，67个赠款提交与30个资助，并在医学和塔斯基吉大学莫尔豪斯学校产生了重大影响。自2010年以来，我们已经招募了47名研究人员参加癌症中心的多个项目。 2011年制定的战略计划与转化治疗，系统生物医学，能量学和癌症的交叉主题今天仍然具有高度相关性。未来，我们将继续强调转化和癌症差异研究，重点是个性化/基因组医学，能量平衡和癌症，结果和生存率以及早期临床试验。

PROJECT SUMMARY/ ABSTACT The UAB CCC is the only NCI designated comprehensive cancer center in the states of Alabama, Mississippi, Louisiana and Arkansas, states with higher cancer mortality and significant minority, mostly African American populations. The Cancer Center is in its 44th year of NCI funding and continues its major contributions to translational therapeutics and cancer disparity research with a focus on training minority investigators. The UAB CCC has 242 members who come from 30 departments in 9 UAB schools, Southern Research, and HudsonAlpha Institute for Biotechnology. The members are supported by $92,055,777 in annual direct extramural funding. The UAB CCC is organized into six research programs, two each in basic, translational, and prevention and control – Inflammation, Immunology & Immunotherapeutics; Cancer Cell Biology; Experimental Therapeutics; Neuro-Oncology; Cancer Chemoprevention; and Cancer Control & Population Sciences. Members published 1,684 cancer focused, peer reviewed publications between 2011 and 2015 of which 24% were intra-programmatic, 16% inter-programmatic, and 53% inter-institutional. These members are supported by eleven shared facilities – Biostatistics & Bioinformatics, Comprehensive Genomics, High Resolution Imaging, Human Imaging, Mass Spectrometry/2D Proteomics, Microbiome/Gnotobiotic, Preclinical Imaging, Recruitment & Retention, Structural Biology, Tissue Procurement, and Transgenic Animals as well as the developing Pharmacometrics Shared Facility. We have established a Phase I Clinical Trials Program, opened an Advanced Imaging Facility, advanced targets through the Alabama Drug Discovery Alliance, created the UAB Health System Cancer Community Network, and are now a consortium with HudsonAlpha Institute for Biotechnology. In addition to these achievements, we have created an Institute for Cancer Outcomes and Survivorship, and established a critical mass of investigators in energy balance and cancer. We have also expanded our minority training programs that since 2005 have trained 59 scholars resulting in 306 publications, 67 grant submissions with 30 funded, and have had a major impact at Morehouse School of Medicine and Tuskegee University. We have recruited 47 investigators to multiple programs in the Cancer Center since 2010. Strategic plans developed in 2011 with crosscutting themes of Translational Therapeutics, Systems Biomedicine, and Energetics and Cancer continue to be highly relevant today. For the future, we will continue to emphasize translational and cancer disparity research with an emphasis on personalized/genomic medicine, energy balance and cancer, outcomes and survivorship, and early phase clinical trials.