BlueRemediomics: Harnessing the marine microbiome for novel sustainable biogenics and ecosystem services

海洋微生物群落在地球上发挥着维持生命的关键功能，是一个巨大的未开发的生物资源宝库，有可能加强欧洲的蓝色经济。要释放这种隐藏的潜力，以及负责任地从海洋微生物中进行生物发现，需要多方面的发展。我们需要融合和应用先进技术，以阐明海洋微生物群的组成、相互作用和功能谱系，同时确保可持续和公平的开发，维护海洋健康，并通过提高对海洋微生物的欣赏来提高海洋素养。为了满足这些需求，BlueRemediology将：(1)开发和提供一个综合生物信息学平台，以挖掘海洋微生物群的潜力；(2)建立创新的文化生物学和高通量筛选平台，以试验利用海洋微生物群组；(3)利用这些平台来确定和开发源自海洋微生物的天然产品；(4)促进体现“不造成重大伤害”原则的水产养殖和生态系统服务；(5)最大限度地公平获得海洋微生物群资源，提高不同利益攸关方对海洋微生物群的认识；(6)为各种利益攸关方提供培训、工具和资源。为了实现这些目标，BlueRemediology将先进的“发现平台”与“应用程序”联系在一起，旨在促进循环和迭代串扰。通过联合多个目前支离破碎的关键数据资源，Discovery平台将加快新产品的识别和开发，减少对资源的依赖，提高消费者利益，并解决关键的社会问题。将建立获取和惠益分享的新模式，在可持续和公平利用海洋遗传资源与知识产权保护之间取得平衡。

Marine microbial communities perform critical life sustaining functions on Earth and represent a vast unexploited treasure trove of bioresources that have the potential to strengthen the European blue economy. To unlock this hidden potential, as well as responsibly conduct biodiscovery from marine microbes requires multiple developments. We need to amalgamate and apply advanced technologies to elucidate the composition, interactions and functional repertoire of the marine microbiome, while concomitantly ensuring sustainable and equitable exploitation, maintaining ocean health, and improving ocean literacy through an improved appreciation of ocean microbes. To address these needs, BlueRemediomics will: (1) develop and provide an integrated bioinformatics platform to explore the marine microbiome potential; (2) establish innovative culturomics and high-throughput screening platforms to experimentally exploit consortia of marine microbes; (3) apply the platforms to identify and develop natural products derived from marine microbes; (4) foster aquaculture and ecosystem services that embody the “do no significant harm” principle; (5) maximise equitable access to ocean microbiome resources and increase awareness of the marine microbiome to a diverse range of stakeholders; (6) Provide training, tools and resources to a variety of stakeholders. To achieve these objectives, BlueRemediomics interlinks an advanced “Discovery Platform” with “Applications”, so designed to facilitate cyclical and iterative crosstalk. By federating multiple, currently fragmented key data resources, the Discovery Platform will accelerate new product identification and development, reduce resource dependence, raise consumer benefits and address key societal issues. New modalities in access and benefit sharing will be established that balance sustainable and equitable use of marine genetic resources with intellectual property protection.