A Role for the Astrocytic Network in Spatial Navigation

空间导航为所有动物物种提供了一种适应优势，优化了 生存和繁殖。这种行为涉及大量的大脑结构和认知 功能，从自我运动和环境线索的感知开始，到建筑空间 表述和目标整合。海马体结构对 为导航和规划建立、维护和更新空间地图。这个项目 将探索海马星形细胞网络在空间导航和衰老相关中的作用 空间导航缺陷。我们将开发药物操作来拯救行为 衰老小鼠的缺陷。该项目将加强我们对海马体作用的理解 空间导航中的解剖学和连通性，即潜在的行为生物学过程 老年人的缺陷，并将有助于在动物模型中开发新的补救策略， 可能对临床治疗产生后续影响。

Spatial navigation affords an adaptive advantage for all animal species, optimizing chances of survival and reproduction. This behavior involves a multitude of brain structures and cognitive functions, starting from perception of self-motion and environmental cues, to building spatial representations and goal integration. The hippocampus formation is particularly important for the building, maintaining, and updating spatial maps for navigation and planning. This project will explore the role of hippocampal astrocytic networks in spatial navigation and aging-related spatial navigation deficits. We will develop pharmacological manipulations to rescue behavioral deficits in aged mice. The project will enhance our understanding of the role of the hippocampal anatomy and connectivity in spatial navigation, the biological processes underlying behavioral deficits in aged individuals, and will help develop new remedial strategies in animal models, with possible subsequent impact on clinical treatments.