Hepatic steatosis promotes liver metastasis

项目摘要/摘要 早期乳腺癌的治疗有了很大的进步，但预防转移仍然是一个更重要的问题 难以捉摸的目标。肥胖在我们的社会中是地方病，它与乳腺癌风险的增加有关 并加速转移。肥胖影响乳腺癌患者生存的方式是， 然而，人们对此知之甚少。肝脏是乳腺癌最常见的转移部位之一，其 其发生通常与预后不良有关。肝脏健康与体重密切相关，因为肥胖是 脂肪肝的主要原因，据估计，四分之一到三分之一的美国人患有脂肪肝。 我们发现，脂肪肝通过为肿瘤提供燃料，显著增加了小鼠的肝脏转移。 细胞，从而加速它们的生长。对人类肝脏活检的检查和核磁共振分析也表明了这一点。 在患有转移性乳腺癌的女性身上也是如此。因此，我们的第一个目标是确定是否治疗脂肪肝 减少乳腺癌的肝转移，改善其对化疗的反应。找出潜在的新消息 肝转移的治疗我们将探索脂肪肝刺激肿瘤的机制 成长。最后，我们将问，人类乳腺癌是否表现出与其他乳腺癌相同的肝转移特性。 在老鼠身上。如果我们的结论属实，乳腺癌的治疗将普遍需要预防和治疗。 脂肪肝病的风险，因此影响所有受影响的妇女。浅谈我国脂肪肝的防治 然而，乳腺癌患者可能会减少肝脏转移，从而延长生存时间。因为胖子 肝脏疾病通常是肥胖的产物，教育患者卡路里的摄入，这是可以发生的 即刻，可能对乳腺癌的预后有重大影响。

Project Summary/Abstract Treatment of early stage breast cancer has substantially improved but preventing metastasis remains a more elusive target. Obesity, which is endemic in our society, is associated with an increased risk of breast cancer and accelerated metastasis. The means by which obesity compromises survival of breast cancer patients is, however, poorly understood. Liver is among the most common sites of breast cancer metastasis and its occurrence is generally associated with poor prognosis. Liver health is closely related to weight as obesity is the major cause of fatty liver disease, estimated to be present in 1/4 to 1/3 of Americans. We discovered that fatty liver disease markedly increases liver metastasis, in mice, by providing fuel to tumor cells thereby accelerating their growth. Examination of human liver biopsies and MRI analysis suggests the same is true in women with metastatic breast cancer. Thus, our first goal is to determine if treating fatty liver disease reduces breast cancer liver metastasis and improves its response to chemotherapy. To identify potential new treatments for liver metastasis we will explore the mechanisms by which fatty liver disease stimulates tumor growth. Finally, we will ask if human breast cancers exhibit the same liver metastatic properties as those arising in mice. If our conclusion proves true, treatment of breast cancer will universally require prevention and treatment of fatty liver disease and therefore impact all affected women. Prevention and treatment of fatty liver disease in breast cancer patients, however, may likely reduce liver metastasis and therefore prolong survival. Because fatty liver disease is most often the product of obesity, educating patients about calorie intake, which can be instituted immediately, may have significant effects on breast cancer prognosis.